Current systemic dosages of chemotherapeutic drugs such as gemcitabine, 5-FU, cisplatin,
doxorubicin are administered every 7 days over 4 cycles due to systemic toxicity. An …

Background Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing
compounds with good safety profiles which have been investigated for their benefits and …

The combinations of Bromelain and Acetylcysteine (BromAc®) with cytotoxics such as
Gemcitabine, 5-Fluorouracil or Oxaliplatin have shown a dramatic reduction in IC50 values …

Intraperitoneal chemotherapy together with cytoreductive surgery is the standard of care for
a number of peritoneal surface malignancies. However, this approach fails to maintain the …

Purpose: This study assessed the cytotoxic effects of the nucleoside analog gemcitabine in
combination with the diaminocyclohexane platinum compound oxaliplatin. Methods: Growth …

Objectives: To identify synergistic combinations of clinically available agents with zoledronic
acid which would enhance antitumor activity as measured by median effect isobologram …

Background Gemcitabine, a deoxycytidine nucleoside analog, is the current standard
chemotherapy used as first-line treatment for patients with locally advanced or metastatic …

AIM: To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepaoma cell line
(7721). METHODS: The median-effect principle was used. RESULTS: Killing effects of the …

Combination chemotherapy is commonly used to treat late stage cancer; however, treatment
is often limited by systemic toxicity. Optimizing drug ratio and schedule can improve drug …

The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …