Spectinamides are novel amide derivatives of the antibiotic spectinomycin that have
emerged as a new class of agents to treat tuberculosis. These agents showed potent in vitro …

Spectinamides are new semi-synthetic spectinomycin derivatives with potent anti-tubercular
activity. The reported synergism of the precursor spectinomycin with other antibiotics …

Spectinamides are a novel series of spectinomycin analogs being developed for the
treatment of tuberculosis. The preclinical lead spectinamide 1599 is an antituberculosis drug …

Objectives: New drug regimens employing combinations of existing and experimental
antimicrobial agents are needed to shorten treatment of tuberculosis (TB) in humans. The …

The lengthy treatment time for tuberculosis (TB) is a primary cause for the emergence of
multidrug resistant tuberculosis (MDR-TB). One approach to improve TB therapy is to …

Spectinamides are a novel class of narrow-spectrum antitubercular agents with the potential
to treat drug-resistant tuberculosis infections. Spectinamide 1810 has shown a good safety …

Spectinamides are a novel series of spectinomycin analogs being developed for the
treatment of tuberculosis. Intrapulmonary aerosol (IPA) administration of lead spectinamide …

The spectinamides are novel, narrow-spectrum semisynthetic analogs of spectinomycin,
modified to avoid intrinsic efflux by Mycobacterium tuberculosis. Spectinamides, including …

Although the classical antibiotic spectinomycin is a potent bacterial protein synthesis
inhibitor, poor antimycobacterial activity limits its clinical application for treating tuberculosis …

New chemotherapeutic agents are urgently needed to control the spread of multidrug-
resistant (MDR) and extensively drug-resistant (XDR) forms of tuberculosis, which still …