Transforming growth factor-β receptors and Smads: regulatory complexity and functional versatility

EH Budi, D Duan, R Derynck - Trends in cell biology, 2017 - cell.com
Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and
growth, and direct cell differentiation, thus playing key roles in normal development and …

Negative regulation of TGF-β receptor/Smad signal transduction

S Itoh, P ten Dijke - Current opinion in cell biology, 2007 - Elsevier
Members of the transforming growth factor-β (TGF-β) family are highly conserved
multifunctional cell–cell signaling proteins that are of key importance for controlling …

New insights into TGF-β–Smad signalling

P ten Dijke, CS Hill - Trends in biochemical sciences, 2004 - cell.com
Transforming growth factor β (TGF-β) initiates its diverse cellular responses by binding to
and activating specific cell surface receptors that have intrinsic serine/threonine kinase …

TGF-β signaling from receptors to Smads

A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

[HTML][HTML] Post-translational regulation of TGF-β receptor and Smad signaling

P Xu, J Liu, R Derynck - FEBS letters, 2012 - Elsevier
TGF-β family signaling through Smads is conceptually a simple and linear signaling
pathway, driven by sequential phosphorylation, with type II receptors activating type I …

Specificity, diversity, and regulation in TGF‐β superfamily signaling

E Piek, CH HELDIN, PTEN DIJKE - The FASEB Journal, 1999 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) superfamily members are multifunctional cell‐cell
signaling proteins that play pivotal roles in tissue homeostasis and development of …

New regulatory mechanisms of TGF-β receptor function

JS Kang, C Liu, R Derynck - Trends in cell biology, 2009 - cell.com
Transforming growth factor-β (TGF-β) regulates cell proliferation, differentiation and
apoptosis, and TGF-β-related proteins have key roles in development, tissue homeostasis …

Posttranslational regulation of Smads

P Xu, X Lin, XH Feng - Cold Spring Harbor perspectives …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) family signaling dictates highly complex programs of
gene expression responses, which are extensively regulated at multiple levels and vary …

Non-Smad signaling pathways of the TGF-β family

YE Zhang - Cold Spring Harbor perspectives in biology, 2017 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and structurally related factors use several intracellular
signaling pathways in addition to Smad signaling to regulate a wide array of cellular …

TGFβ–SMAD signal transduction: molecular specificity and functional flexibility

B Schmierer, CS Hill - Nature reviews Molecular cell biology, 2007 - nature.com
Ligands of the transforming growth factor-β (TGFβ) superfamily of growth factors initiate
signal transduction through a bewildering complexity of ligand–receptor interactions …