Longitudinal motor system changes from acute to chronic spinal cord injury

TM Emmenegger, D Pfyffer, A Curt… - European Journal of …, 2024 - Wiley Online Library
Background and purpose In acute spinal cord injury (SCI), magnetic resonance imaging
(MRI) reveals tissue bridges and neurodegeneration for 2 years. This 5‐year study aims to …

Tracking sensory system atrophy and outcome prediction in spinal cord injury

P Grabher, MF Callaghan, J Ashburner… - Annals of …, 2015 - Wiley Online Library
Objective In patients with subacute spinal cord injury (SCI), the motor system undergoes
progressive structural changes rostral to the lesion, which are associated with motor …

[HTML][HTML] Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury

M Seif, A Curt, AJ Thompson, P Grabher, N Weiskopf… - NeuroImage: Clinical, 2018 - Elsevier
Objective To reveal the immediate extent of trauma-induced neurodegenerative changes
rostral to the level of lesion and determine the predictive clinical value of quantitative MRI …

[HTML][HTML] Dynamics of progressive degeneration of major spinal pathways following spinal cord injury: A longitudinal study

S Schading, G David, TM Emmenegger, C Achim… - NeuroImage: Clinical, 2023 - Elsevier
Background Following spinal cord injury (SCI), disease processes spread gradually along
the spinal cord forming a spatial gradient with most pronounced changes located at the …

[HTML][HTML] Relationship between brainstem neurodegeneration and clinical impairment in traumatic spinal cord injury

P Grabher, C Blaiotta, J Ashburner, P Freund - NeuroImage: Clinical, 2017 - Elsevier
Background Brainstem networks are pivotal in sensory and motor function and in recovery
following experimental spinal cord injury (SCI). Objective To quantify neurodegeneration …

Can Magnetic Resonance Imaging Reveal Lower Motor Neuron Damage after Traumatic Spinal Cord Injury? A Scoping Review

J Moneo, JLK Kramer, TE Nightingale… - Neurotrauma …, 2021 - liebertpub.com
Restoring muscle function to patients with spinal cord injuries (SCIs) will invariably require a
functioning lower motor neuron (LMN). As techniques such as nerve transfer surgery …

Tracking changes following spinal cord injury: insights from neuroimaging

P Freund, A Curt, K Friston… - The Neuroscientist, 2013 - journals.sagepub.com
Traumatic spinal cord injury is often disabling and recovery of function is limited. As a
consequence of damage, both spinal cord and brain undergo anatomical and functional …

Longitudinal changes of spinal cord grey and white matter following spinal cord injury

G David, D Pfyffer, K Vallotton, N Pfender… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objectives Traumatic and non-traumatic spinal cord injury produce neurodegeneration
across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and …

Motor recovery at 6 months after admission is related to structural and functional reorganization of the spine and brain in patients with spinal cord injury

J Hou, Z Xiang, R Yan, M Zhao, Y Wu… - Human brain …, 2016 - Wiley Online Library
This study aimed to explore structural and functional reorganization of the brain in the early
stages of spinal cord injury (SCI) and identify brain areas that contribute to motor recovery …

Progressive neurodegeneration following spinal cord injury: implications for clinical trials

G Ziegler, P Grabher, A Thompson, D Altmann… - Neurology, 2018 - AAN Enterprises
Objective To quantify atrophy, demyelination, and iron accumulation over 2 years following
acute spinal cord injury and to identify MRI predictors of clinical outcomes and determine …