High-fat feeding activates components of the pro-inflammatory pathway and increases co-
immunoprecipitation of suppressor of cytokine signalling (SOCS)-3 with both the insulin …

Intense resistance exercise causes a significant inflammatory response. NF-κB has been
identified as a prospective key transcription factor mediating the postexercise inflammatory …

Two studies were performed to investigate the effects of an acute bout of physical exercise
on the nuclear protein κb (nf‐κb) signaling pathway in rat skeletal muscle. In Study 1, a …

Muscle protein synthesis and mTORC1 signalling are concurrently stimulated following
muscle contraction in humans. In an effort to determine whether mTORC1 signalling is …

Insulin signaling plays a key role in glucose uptake, glycogen synthesis, and protein and
lipid synthesis. In insulin-resistant states like obesity and type 2 diabetes mellitus, these …

One exercise session can improve subsequent insulin-stimulated glucose uptake by skeletal
muscle in healthy and insulin-resistant individuals. Our first aim was to determine whether a …

The NF-κB signalling pathway plays a critical role in inflammation, immunity, cell
proliferation, apoptosis, and muscle metabolism. NF-κB is activated by extracellular signals …

Background Skeletal muscle mass is determined by the balance between protein synthesis
and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master …

Resistance exercise (RE) activates signalling by the mammalian target of rapamycin
(mTOR) and it has been suggested that rapamycin-sensitive mTOR signalling controls RE …

Resistance training results in skeletal muscle hypertrophy, but the molecular signalling
mechanisms responsible for this altered phenotype are incompletely understood. We used a …