Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training‐accustomed individuals

K Vissing, SL McGee, J Farup… - … journal of medicine …, 2013 - Wiley Online Library
The influence of adenosine mono phosphate (AMP)‐activated protein kinase (AMPK) vs Akt‐
mammalian target of rapamycin C 1 (mTORC1) protein signaling mechanisms on converting …

Contraction‐regulated mTORC1 and protein synthesis: Influence of AMPK and glycogen

JR Knudsen, Z Li, KW Persson, J Li… - The Journal of …, 2020 - Wiley Online Library
Key points AMP‐activated protein kinase (AMPK)‐dependent Raptor Ser792
phosphorylation does not influence mechanistic target of rapamycin complex 1 (mTORC1) …

Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B-and growth factor-independent mechanism

TA Hornberger, R Stuppard, KE Conley… - Biochemical …, 2004 - portlandpress.com
In response to growth factors, mTOR (mammalian target of rapamycin) has been identified
as a central component of the signalling pathways that control the translational machinery …

Akt signalling through GSK‐3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy

B Léger, R Cartoni, M Praz, S Lamon… - The Journal of …, 2006 - Wiley Online Library
Skeletal muscle size is tightly regulated by the synergy between anabolic and catabolic
signalling pathways which, in humans, have not been well characterized. Akt has been …

Normal hypertrophy accompanied by phosphoryation and activation of AMP‐activated protein kinase α1 following overload in LKB1 knockout mice

SL McGee, KJ Mustard, DG Hardie… - The Journal of …, 2008 - Wiley Online Library
The activation of the AMP‐activated protein kinase (AMPK) and inhibition of the mammalian
target of rapamycin complex 1 (mTORC1) is hypothesized to underlie the fact that muscle …

Intramuscular anabolic signaling and endocrine response following resistance exercise: implications for muscle hypertrophy

AM Gonzalez, JR Hoffman, JR Stout, DH Fukuda… - Sports medicine, 2016 - Springer
Maintaining skeletal muscle mass and function is critical for disease prevention, mobility and
quality of life, and whole-body metabolism. Resistance exercise is known to be a major …

[HTML][HTML] ATP-induced increase in intracellular calcium levels and subsequent activation of mTOR as regulators of skeletal muscle hypertrophy

N Ito, UT Ruegg, S Takeda - International journal of molecular sciences, 2018 - mdpi.com
Intracellular signaling pathways, including the mammalian target of rapamycin (mTOR) and
the mitogen-activated protein kinase (MAPK) pathway, are activated by exercise, and …

Effects of age and sedentary lifestyle on skeletal muscle NF-κB signaling in men

TW Buford, MB Cooke, TM Manini… - … Series A: Biomedical …, 2010 - academic.oup.com
Background. Nuclear factor kappa B (NF-κB) is a critical signaling molecule of disuse-
induced skeletal muscle atrophy. However, few studies have carefully investigated whether …

Contraction mode itself does not determine the level of mTORC1 activity in rat skeletal muscle

S Ato, Y Makanae, K Kido, S Fujita - Physiological reports, 2016 - Wiley Online Library
Resistance training with eccentric contraction has been shown to augment muscle
hypertrophy more than other contraction modes do (ie, concentric and isometric contraction) …

Resistance exercise-induced S6K1 kinase activity is not inhibited in human skeletal muscle despite prior activation of AMPK by high-intensity interval cycling

W Apró, M Moberg, DL Hamilton… - American Journal …, 2015 - journals.physiology.org
Combining endurance and strength training in the same session has been reported to
reduce the anabolic response to the latter form of exercise. The underlying mechanism …