RYTHROPOIETIN (EPO) is the principal growth factor E that promotes the viability,
proliferation, and differentiation of mammalian erythroid progenitor cells, functions that are …

We have probed the interaction of human erythropoietin (EPO) with its receptor (EPO-R) by
analyzing a panel of 17 EPO mutants in a variety of in vitro assays. Mutant proteins were …

We have isolated and characterized a genomic clone of the human erythropoietin (Epo)
receptor from a placental genomic library using a cDNA probe for the murine Epo receptor …

Members of the cytokine receptor superfamily have structurally similar extracellular ligand-
binding domains yet diverse cytoplasmic regions lacking any obvious catalytic domains …

Ectopic expression of the erythropoietin receptor (EPO-R) in Ba/F3, an interleukin 3-
dependent progenitor cell line, confers EPO-dependent cell growth. To examine whether the …

Erythropoietin (EPO) stimulates proliferation and differentiation of erythroid progenitor cells.
Several lines of evidence indicate that the most likely mechanism of EPO receptor (EPO-R) …

The erythropoietin receptor (EPO-R) is a member of the recently described cytokine receptor
superfamily. A constitutively active (hormone independent) form of the EPO-R was isolated …

The process of erythropoiesis in the fetal liver and adult bone marrow is regulated by the
hormone erythropoietin (Epo), which is produced in the kidney at low levels under …

The cytoplasmic domain of the cloned erythropoietin (EPO) receptor (EPOR) contains no
protein kinase motif, yet addition of EPO to EPO-responsive cells causes an increase in …

Erythrocyte development in mammals depends in part upon the interaction of the
glycopeptide hormone erythropoietin (EPO) with cell surface receptors on committed …