Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …

The prion paradigm is increasingly invoked to explain the molecular pathogenesis of
neurodegenerative diseases involving the misfolding and aggregation of proteins other than …

A common pathological hallmark among different neurodegenerative diseases is the
accumulation of aggregated proteins that might cause cellular dysfunction and, eventually …

A plethora of evidence suggests that protein misfolding and aggregation are underlying
mechanisms of various neurodegenerative diseases, such as prion diseases and …

Many non-infectious neurodegenerative diseases are associated with the accumulation of
fibrillar proteins. These diseases all exhibit features that are reminiscent of those of …

The misfolding and aggregation of specific proteins is a common hallmark of many
neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and …

Prefibrillar oligomers of the β-amyloid peptide (Aβ) are recognized as potential mediators of
Alzheimer's disease (AD) pathophysiology. Deficits in synaptic function, neurotoxicity, and …

The pathological features of Alzheimer's disease (AD) include senile plaques induced by
amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of …

Prion disease research has contributed much toward understanding other
neurodegenerative diseases, including recent demonstrations that Alzheimer's disease (AD) …

The misfolding and aggregation of specific proteins within nervous system occur in most age-
associated neurodegenerative diseases including Alzheimer's disease (AD). This kind of …