The present research work describes the downstreaming of nattokinase (NK) produced by
Bacillus subtilis under solid state fermentation; and the role of efficient oral formulation of …

Cardiovascular disease (CVD) has become the leading cause of death globally. Nattokinase
(NK), as a novel thrombolytic agent, has gained more and more attention. However, NK is …

Nattokinase (NK) is a thrombolytic enzyme extracted from natto, which can be used to
prevent and treat blood clots. However, it is sensitive to the environment, especially the …

Background Nattokinase (NK) is a serine protease enzyme of the subtilisin family. It exhibits
a strong fibrinolytic activity. The fibrinolytic enzymes from Bacillus sp. have attracted interest …

Background: Nattokinase is a potent fibrinolytic protease, which is used as a drug for
treatment or a supplement for preventing thrombosis besides various industrial applications …

Nattokinase is a potent fibrinolytic enzyme which was first found in a traditional Japanese
soybean food. Two Nattokinase genes were cloned using chromosomal DNA from Bacillus …

Thrombus-related diseases have a high mortality rate and are seriously threatening human
life and health. Nattokinase (NK), which has a strong thrombolytic effect, can treat thrombotic …

In the recent years, nattokinase is one of the most-often employed among the several
thrombolytic agents used clinically, particularly because of its lower cost comparing to other …

Thrombosis has threatened human health in past decades. Bacillus nattokinase is a
potential low-cost thrombolytic drug without side-effects and has been introduced into the …

Nattokinase is a potent fibrinolytic enzyme. The composition of the medium for the
production of nattokinase was optimized with a stepwise strategy. Effects of various nitrogen …