Growing evidence suggests that amyloid beta (Aβ) and tau pathologies are strongly
associated with mitochondrial dysfunction and neuronal damage in Alzheimer's disease …

Mitochondrial dysfunction is likely a significant contributing factor to Alzheimer disease
pathogenesis, and both amyloid peptide (Aβ) and pathological forms of tau may contribute to …

Alzheimer's disease (AD) is characterized by the presence of aggregates of tau protein. Tau
truncated by caspase-3 (D421) or tau hyperphosphorylated at Ser396/S404 might play a …

Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved
in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions …

Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in
the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a …

The purpose of our study was to understand the toxic effects of hippocampal phosphorylated
tau in tau mice. Using rotarod and Morris water maze (MWM) tests, immunoblotting and …

The energy demand and calcium buffering requirements of the brain are met by the high
number of mitochondria in neurons and in these, especially at the synapses. Mitochondria …

Neurofibrillary tangles (NFT), intracellular inclusions of abnormal fibrillar forms of
microtubule associated protein tau, accumulate in Alzheimer's disease (AD) and other …

The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates
of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by …

Tau is an essential protein that physiologically promotes the assembly and stabilization of
microtubules, and participates in neuronal development, axonal transport, and neuronal …