[HTML][HTML] Homeobox oncogene activation by pan-cancer DNA hypermethylation
Background Cancers have long been recognized to be not only genetically but also
epigenetically distinct from their tissues of origin. Although genetic alterations underlying …
epigenetically distinct from their tissues of origin. Although genetic alterations underlying …
[HTML][HTML] An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer
Background One of the most important recent findings in cancer genomics is the
identification of novel driver mutations which often target genes that regulate genome-wide …
identification of novel driver mutations which often target genes that regulate genome-wide …
A DNA hypermethylation module for the stem/progenitor cell signature of cancer
H Easwaran, SE Johnstone, L Van Neste… - Genome …, 2012 - genome.cshlp.org
Many DNA-hypermethylated cancer genes are occupied by the Polycomb (PcG) repressor
complex in embryonic stem cells (ESCs). Their prevalence in the full spectrum of cancers …
complex in embryonic stem cells (ESCs). Their prevalence in the full spectrum of cancers …
[HTML][HTML] Pan-cancer analysis of frequent DNA co-methylation patterns reveals consistent epigenetic landscape changes in multiple cancers
Background DNA methylation is the major form of epigenetic modifications through which
the cell regulates the gene expression and silencing. There have been extensive studies on …
the cell regulates the gene expression and silencing. There have been extensive studies on …
[HTML][HTML] A DNA methylation map of human cancer at single base-pair resolution
Although single base-pair resolution DNA methylation landscapes for embryonic and
different somatic cell types provided important insights into epigenetic dynamics and cell …
different somatic cell types provided important insights into epigenetic dynamics and cell …
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
Extensive changes in DNA methylation are common in cancer and may contribute to
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
[HTML][HTML] Methylation status of homeobox genes in common human cancers
MFSD Rodrigues, CM Esteves, FCA Xavier, FD Nunes - Genomics, 2016 - Elsevier
Approximately 300 homeobox loci were identified in the euchromatic regions of the human
genome, of which 235 are probable functional genes and 65 are likely pseudogenes. Many …
genome, of which 235 are probable functional genes and 65 are likely pseudogenes. Many …
Comparative pan-cancer DNA methylation analysis reveals cancer common and specific patterns
Abnormal DNA methylation is an important epigenetic regulator involving tumorigenesis.
Deciphering cancer common and specific DNA methylation patterns is essential for us to …
Deciphering cancer common and specific DNA methylation patterns is essential for us to …
[HTML][HTML] Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
Background One of the hallmarks of cancer is the disruption of gene expression patterns.
Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA …
Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA …
Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …