Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy, exhibiting
a unique capacity to self-renew and differentiate into all blood cells throughout the lifetime …

The limited number of human hematopoietic stem cells (HSCs) has restrained their
widespread clinical application. Despite great efforts in recent years, the in vitro expansion …

Hematopoietic stem cells (HSCs) are characterized by the ability to self-renew and to
replenish the hematopoietic system. The cell-cycle kinase cyclin-dependent kinase 6 …

The widespread clinical application of cord blood (CB) for hematopoietic stem cell (HSC)
transplantation is limited mainly by the inadequate number of hematopoietic stem and …

Hematopoietic stem cells (HSCs) undergo self-renewal or differentiation to sustain lifelong
hematopoiesis. HSCs are preserved in quiescence with low mitochondrial activity. Recent …

Steady-state hematopoiesis is sustained through differentiation balanced with proliferation
and self-renewal of hematopoietic stem cells (HSCs). Disruption of this balance can lead to …

Background Adult hematopoietic stem cells (HSCs) homeostasis is critically important in
maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its homeostasis …

Hematopoietic stem cells (HSCs) are able to self-renew and to differentiate into all blood
cells. HSCs reside in a low-perfusion niche and depend on local signals to survive and to …

Hematopoietic stem cell (HSC) homeostasis depends on the balance between self renewal
and lineage commitment, but what regulates this decision is not well understood. Using loss …

Inhibition of autophagy has been proposed as a potential therapy for individuals with cancer.
However, current lysosomotropic autophagy inhibitors have demonstrated limited efficacy in …