Most of the known regulatory mechanisms that curb inflammatory gene expression target pre–
transcription-initiation steps, and evidence for post-initiation regulation of inflammatory gene …

In this issue of JEM, Zhang et al.(https://doi. org/10.1084/jem. 20171417) show that the
suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation …

Complex organisms can rapidly induce select genes in response to diverse environmental
cues. This regulation occurs in the context of large genomes condensed by histone proteins …

Chromatin undergoes extensive reprogramming during immune cell differentiation. Here we
report the repression of controlled histone H3 amino terminus proteolytic cleavage (H3ΔN) …

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A subset of inflammatory-response NF-κB target genes is activated immediately following
pro-inflammatory signal. Here we followed the kinetics of primary transcript accumulation …

Studies on macrophage gene expression have historically focused on events leading to
RNA polymerase II recruitment and transcription initiation, whereas the contribution of post …

Epigenetic modifiers have fundamental roles in defining unique cellular identity through the
establishment and maintenance of lineage-specific chromatin and methylation status …

Hexim1 acts as a tumor suppressor and is involved in the regulation of innate immunity. It
was initially described as a non-coding RNA-dependent regulator of transcription. Here, we …

IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls
the induction of a gene expression program whose products execute inhibitory effects on …