The human Src homology and collagen (Shc) gene encodes three protein isoforms of 46,
52, and 66 kDa that belong to a family of molecular adapters involved in several signal …

Abstract p66Shc promotes apoptosis and controls the intracellular redox balance. A fraction
of p66Shc exists within mitochondria, where it oxidizes cytochrome c to form hydrogen …

The mammalian Shc family, composed of p46, p52, and p66 isoforms, serves as an adaptor
protein in cell growth and stress response. p66Shc was shown to be a negative lifespan …

Mitochondria contribute to various diseases and aging phenotypes. Reactive oxygen
species (ROS), mainly formed by the respiratory chain, were long thought to cause these …

p66Shc protein has been proposed to be an indispensable factor for p53-dependent,
mitochondria-mediated apoptosis in mice. Here, we show that p66Shc plays a pro-apoptotic …

Although the p46Shc isoform has been known to be mitochondrially localized for 11 years,
its function in mitochondria has been a mystery. We confirmed p46Shc to be mitochondrially …

p66Shc, a 66 kDa proto-oncogene Src collagen homologue (Shc) adaptor protein, is
classically known as a signalling protein implicated in receptor tyrosine kinase signal …

Previous studies have determined that mice with a homozygous deletion in the adapter
protein p66 shc have an extended life span and that cells derived from these mice exhibit …

Abstract p66Shc, a member of the ShcA (Src homologous-collagen homologue) adaptor
protein family, is one of the three isoforms of this family along with p46Shc and p52Shc …

Shc (Src homology and collagen homology) proteins are considered prototypical signalling
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …