Resistance to conventional chemotherapeutic agents, including irinotecan (CPT‑11), 5-
fluorouracil and capecitabine is a major cause for therapeutic failure in patients with …

Natural compounds such as curcumin have the ability to enhance the therapeutic
effectiveness of common chemotherapy agents through cancer stem‑like cell (CSC) …

Purpose Recurrence of colon cancer, which affects nearly 50% of patients treated by
conventional therapeutics, is thought to be due to re-emergence of chemotherapy-resistant …

Colorectal cancer is one of the commonest cancers in the world and it is also a common
cause of cancer-related death worldwide. Despite advanced treatment strategies, the …

Curcumin is known to induce apoptosis of cancer cells by different mechanisms, but its
effects on cancer stem cells (CSC) have been less investigated. Here, we report that …

Background Many cancers contain cell subpopulations that display characteristics of stem
cells. Because these cancer stem cells (CSCs) appear to provide resistance to chemo …

Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal
cancer chemotherapeutics but with limited success. This could partly be due to the …

Cancer stem cells (CSCs) represent a small subpopulation within a tumour. These cells
possess stem cell-like properties but also initiate resistance to cytotoxic agents, which …

Objective Development of treatment resistance and adverse toxicity associated with
classical chemotherapeutic agents highlights the need for safer and effective therapeutic …

This study investigated the effect of curcumin on colorectal cancer stem cells (CCSCs) and
its possible mechanism. Comparison of the metabolic profiles of human adenomatous polyp …