Abstract The Global Polio Eradication Initiative (GPEI) faces substantial challenges with
managing outbreaks of serotype 2 circulating vaccine-derived polioviruses (cVDPV2s) in …

Objectives The emergence of human pathogens with pandemic potential motivates rapid
vaccine development. We explore the role of vaccines in control and eradication of a novel …

Background Eight outbreaks of paralytic polio attributable to circulating vaccine-derived
poliovirus (cVDPV) have highlighted the risks associated with oral poliovirus vaccine (OPV) …

Background. Oral poliovirus vaccine (OPV) results in an ongoing burden of poliomyelitis due
to vaccine-associated paralytic poliomyelitis and circulating vaccine-derived polioviruses …

Background & aims of study: While wild poliovirus (WPV) types 2 and 3 have been
eradicated and only 22 cases of WPV type 1 were reported in 2022, 675 cases of type-2 …

Poliovirus importations into polio-free countries represent a major concern during the final
phases of global eradication of wild polioviruses (WPVs). We extend dynamic transmission …

Vaccine-derived polioviruses (VDPVs), genetically divergent strains from the oral poliovirus
vaccine (OPV), fall into three classifications: 1) circulating VDPVs (cVDPVs) from outbreaks …

Reversion and spread of vaccine-derived poliovirus (VDPV) to cause outbreaks of
poliomyelitis is a rare outcome resulting from immunisation with the live-attenuated oral …

Democratic Republic of the Congo has had cases of polio caused by vaccine-derived
polioviruses (VDPVs) documented since 2004. The emergence of these VDPVs, which …

In 2015, wild poliovirus (WPV) transmission was identified in only Afghanistan and Pakistan
(1). The widespread use of live, attenuated oral poliovirus vaccine (OPV) has been key in …