Asthma treatment response to inhaled corticosteroids is associated with variants in VEGFA gene
Asthma is a common, chronic disease usually characterized by airway inflammation,
affecting 1–18% of the population worldwide (Initiative, 2020). Airway inflammation is …
affecting 1–18% of the population worldwide (Initiative, 2020). Airway inflammation is …
Integrative approach identifies corticosteroid response variant in diverse populations with asthma
Background Although inhaled corticosteroid (ICS) medication is considered the cornerstone
treatment for patients with persistent asthma, few ICS pharmacogenomic studies have …
treatment for patients with persistent asthma, few ICS pharmacogenomic studies have …
Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review
O Keskin, N Farzan, E Birben, H Akel… - Clinical and …, 2019 - Wiley Online Library
There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While
some of this heterogeneity of response is due to adherence and environmental causes …
some of this heterogeneity of response is due to adherence and environmental causes …
No evidence of large genetic effects on steroid response in asthma patients
M Mosteller, L Hosking, K Murphy, J Shen… - Journal of Allergy and …, 2017 - Elsevier
Background Inhaled corticosteroids (ICSs) are considered the most effective anti-
inflammatory therapy for asthma control and management; however, there is substantial …
inflammatory therapy for asthma control and management; however, there is substantial …
Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use
N Hernandez-Pacheco, SJ Vijverberg… - European …, 2021 - Eur Respiratory Soc
Rationale Substantial variability in response to asthma treatment with inhaled corticosteroids
(ICS) has been described among individuals and populations, suggesting the contribution of …
(ICS) has been described among individuals and populations, suggesting the contribution of …
Nasal gene expression changes with inhaled corticosteroid treatment in asthma
To the Editor, Inhaled corticosteroids (ICS) improve asthma control in most, but not all
patients. 1, 2 Currently, biomarkers that help clinicians to pre‐dict individual ICS …
patients. 1, 2 Currently, biomarkers that help clinicians to pre‐dict individual ICS …
Pharmacogenomics of inhaled corticosteroids and leukotriene modifiers: a systematic review
N Farzan, SJH Vijverberg, HG Arets… - Clinical & …, 2017 - Wiley Online Library
Background Pharmacogenetics studies of anti‐inflammatory medication of asthma have
expanded rapidly in recent decades, but the clinical value of their findings remains limited …
expanded rapidly in recent decades, but the clinical value of their findings remains limited …
Multiomics analysis identifies BIRC3 as a novel glucocorticoid response–associated gene
Background Inhaled corticosteroid (ICS) response among patients with asthma is influenced
by genetics, but biologically actionable insights based on associations have not been found …
by genetics, but biologically actionable insights based on associations have not been found …
Genome-wide association studies of asthma
M Tamari, K Tomita, T Hirota - Allergology international, 2011 - Elsevier
Bronchial asthma is a common inflammatory disease caused by a combination of genetic
and environmental factors. To discover the genes and cellular pathways underlying asthma …
and environmental factors. To discover the genes and cellular pathways underlying asthma …
[HTML][HTML] Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma
A Dahlin, JE Sordillo, M McGeachie, RS Kelly… - PLoS …, 2020 - journals.plos.org
While genome-wide association studies have identified genes involved in differential
treatment responses to inhaled corticosteroids (ICS) in asthma, few studies have evaluated …
treatment responses to inhaled corticosteroids (ICS) in asthma, few studies have evaluated …