Asthma treatment response to inhaled corticosteroids is associated with variants in VEGFA gene

J Debeljak, P Korošec, A Lopert, M Fležar, M Košnik… - Gene, 2021 - Elsevier
Asthma is a common, chronic disease usually characterized by airway inflammation,
affecting 1–18% of the population worldwide (Initiative, 2020). Airway inflammation is …

Integrative approach identifies corticosteroid response variant in diverse populations with asthma

AM Levin, H Gui, N Hernandez-Pacheco… - Journal of Allergy and …, 2019 - Elsevier
Background Although inhaled corticosteroid (ICS) medication is considered the cornerstone
treatment for patients with persistent asthma, few ICS pharmacogenomic studies have …

Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review

O Keskin, N Farzan, E Birben, H Akel… - Clinical and …, 2019 - Wiley Online Library
There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While
some of this heterogeneity of response is due to adherence and environmental causes …

No evidence of large genetic effects on steroid response in asthma patients

M Mosteller, L Hosking, K Murphy, J Shen… - Journal of Allergy and …, 2017 - Elsevier
Background Inhaled corticosteroids (ICSs) are considered the most effective anti-
inflammatory therapy for asthma control and management; however, there is substantial …

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use

N Hernandez-Pacheco, SJ Vijverberg… - European …, 2021 - Eur Respiratory Soc
Rationale Substantial variability in response to asthma treatment with inhaled corticosteroids
(ICS) has been described among individuals and populations, suggesting the contribution of …

Nasal gene expression changes with inhaled corticosteroid treatment in asthma

IM Boudewijn, A Lan, A Faiz, CA Cox, S Brouwer… - Allergy, 2020 - Wiley Online Library
To the Editor, Inhaled corticosteroids (ICS) improve asthma control in most, but not all
patients. 1, 2 Currently, biomarkers that help clinicians to pre‐dict individual ICS …

Pharmacogenomics of inhaled corticosteroids and leukotriene modifiers: a systematic review

N Farzan, SJH Vijverberg, HG Arets… - Clinical & …, 2017 - Wiley Online Library
Background Pharmacogenetics studies of anti‐inflammatory medication of asthma have
expanded rapidly in recent decades, but the clinical value of their findings remains limited …

Multiomics analysis identifies BIRC3 as a novel glucocorticoid response–associated gene

M Kan, AR Diwadkar, H Shuai, J Joo, AL Wang… - Journal of Allergy and …, 2022 - Elsevier
Background Inhaled corticosteroid (ICS) response among patients with asthma is influenced
by genetics, but biologically actionable insights based on associations have not been found …

Genome-wide association studies of asthma

M Tamari, K Tomita, T Hirota - Allergology international, 2011 - Elsevier
Bronchial asthma is a common inflammatory disease caused by a combination of genetic
and environmental factors. To discover the genes and cellular pathways underlying asthma …

[HTML][HTML] Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma

A Dahlin, JE Sordillo, M McGeachie, RS Kelly… - PLoS …, 2020 - journals.plos.org
While genome-wide association studies have identified genes involved in differential
treatment responses to inhaled corticosteroids (ICS) in asthma, few studies have evaluated …