Introduction Asthma is a complex disease with heterogeneous expression/severity. There is
growing interest in defining asthma endotypes consistently associated with different …

There is evidence that genetic factors are implicated in the observed differences in
therapeutic responses to the common classes of asthma therapy such as β2-agonists …

Background Single nucleotide polymorphisms (SNPs) influence a patient's response to
inhaled corticosteroids and β 2-agonists, and the effect of treatment with inhaled …

To the Editor: Inhaled corticosteroids (ICS) are the primary antiinflammatory therapy for the
control and management of asthma, but their effects are characterized by some inter …

There is increasing pharmacogenetic literature on the heterogeneity in the treatment
responses to different anti-asthma drugs including inhaled corticosteroid (ICS), which are …

The astounding number of genetic variants revealed in the 15 years of genome-wide
association studies of asthma has not kept pace with the goals of translational genomics …

Introduction: Inhaled corticosteroids (ICS) are the most common asthma controller
medication. However, a high proportion of patients does not respond to this medication and …

Introduction Older adults have the greatest burden of asthma and poorest outcomes. The
pharmacogenetics of inhaled corticosteroid (ICS) treatment response is not well studied in …

Asthma is a complex phenotype caused by a combination of genetic and environmental
factors that remain poorly understood. The common variants involved in the pathogenesis of …

METHODS: 428 ICS-treated non-Hispanic White (NHW), 192 ICS-treated African American
(AA) asthma subjects from NHLBI Severe Asthma Research Program (SARP) 1 and 2 were …