Exosomal plasminogen activator inhibitor-1 induces ionizing radiation-adaptive glioblastoma cachexia
Cancer cachexia is a muscle-wasting syndrome that leads to a severely compromised
quality of life and increased mortality. A strong association between cachexia and poor …
quality of life and increased mortality. A strong association between cachexia and poor …
Autophagy exacerbates muscle wasting in cancer cachexia and impairs mitochondrial function
F Penna, R Ballarò, P Martinez-Cristobal, D Sala… - Journal of molecular …, 2019 - Elsevier
Cancer cachexia is a multifactorial syndrome characterized by anorexia, weight loss and
muscle wasting that impairs patients' quality of life and survival. Aim of this work was to …
muscle wasting that impairs patients' quality of life and survival. Aim of this work was to …
Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia
Cancer-associated cachexia is a complex metabolic condition characterized by the
progressive loss of body fat and deterioration of muscle mass. Although the cellular and …
progressive loss of body fat and deterioration of muscle mass. Although the cellular and …
Aerobic exercise training and in vivo akt activation counteract cancer cachexia by inducing a hypertrophic profile through eif-2α modulation
MG Pereira, VA Voltarelli, GC Tobias, L de Souza… - Cancers, 2021 - mdpi.com
Simple Summary Chronic disease-related muscle atrophy is a serious public health problem
since it reduces mobility and contributes to increases in hospitalization costs. Unfortunately …
since it reduces mobility and contributes to increases in hospitalization costs. Unfortunately …
Metabolic derangements of skeletal muscle from a murine model of glioma cachexia
Background Cachexia is a complex metabolic disorder and muscle atrophy syndrome,
impacting 80% patients with advanced cancers. Malignant glioma is considered to be one of …
impacting 80% patients with advanced cancers. Malignant glioma is considered to be one of …
Mechanisms of chemotherapy‐induced muscle wasting in mice with cancer cachexia
Background Cachexia is a debilitating complication of cancer characterized by progressive
wasting and weakness of skeletal muscles that reduces quality of life and can compromise …
wasting and weakness of skeletal muscles that reduces quality of life and can compromise …
Cancer cachexia causes skeletal muscle damage via transient receptor potential vanilloid 2‐independent mechanisms, unlike muscular dystrophy
Y Iwata, N Suzuki, H Ohtake… - Journal of cachexia …, 2016 - Wiley Online Library
Background Muscle wasting during cancer cachexia contributes to patient morbidity.
Cachexia‐induced muscle damage may be understood by comparing its symptoms with …
Cachexia‐induced muscle damage may be understood by comparing its symptoms with …
Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: an in vitro and in vivo study
L Yuan, J Han, Q Meng, Q Xi, Q Zhuang… - Oncology …, 2015 - spandidos-publications.com
Abstract Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have
been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in …
been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in …
Exosomes of oral squamous cell carcinoma cells containing miR-181a-3p induce muscle cell atrophy and apoptosis by transmissible endoplasmic reticulum stress …
L Qiu, W Chen, C Wu, Y Yuan, Y Li - Biochemical and Biophysical …, 2020 - Elsevier
Muscle atrophy is a major character of cancer cachexia, whose mechanism remains
enigmatic. During cancer cachexia, the function of endoplasmic reticulum stress (ERS) …
enigmatic. During cancer cachexia, the function of endoplasmic reticulum stress (ERS) …
PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
F Morena da Silva, ME Rosa-Caldwell… - Applied Physiology …, 2022 - cdnsciencepub.com
Cancer cachexia (CC) accounts for 20%–40% of cancer-related deaths. Mitochondrial
aberrations have been shown to precede muscle atrophy in different atrophy models …
aberrations have been shown to precede muscle atrophy in different atrophy models …