Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

Rhodanines and related five-membered heterocycles with multiple heteroatoms have
recently gained a reputation of being unselective compounds that appear as “frequent …

Open-chain dienolate motifs, deriving from deprotonation of a, b-unsaturated carbonyl
compounds, have been recently introduced as practically applicable building blocks for …

Small aromatic ring systems are of central importance in the development of novel synthetic
protein ligands. Here we generate a complete list of 24847 such ring systems. We call this …

Publisher Summary The understanding of the thermodynamics of the events that are
governing molecular recognition is essential for the practice of medicinal chemistry. This …

Here we report a novel modification of our previously reported “Staudinger ligation” that
generates an amide bond from an azide and a specifically functionalized phosphine. This …

Nitrogen-containing stereotriads occur in a number of biologically active compounds, but
general and flexible methods to access these compounds are limited mainly to the …

The oxetane ring is an emergent, underexplored motif in drug discovery that shows attractive
properties such as low molecular weight, high polarity, and marked three-dimensionality …

The choice of an appropriate electrophile is crucial in the design of targeted covalent
inhibitors (TCIs). In this report, we systematically investigated the glutathione (GSH) …

There are many reagents useful for the extension of organic molecules by three carbons
with some functionality at the new terminus. 1 However, to the best of our knowledge, the …