m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma

W Wang, Y Ding, Y Zhao, X Li - Cancer Gene Therapy, 2024 - nature.com
Lymph node metastasis (LNM) is a major cause of locoregional recurrence of papillary
thyroid carcinoma (PTC). However, the mechanisms responsible for LNM are unclear …

[HTML][HTML] RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma …

D Yu, M Pan, Y Li, T Lu, Z Wang, C Liu, G Hu - Journal of Experimental & …, 2022 - Springer
Background Lymph node metastasis is the main cause of poor prognosis of head and neck
squamous carcinoma (HNSCC) patients. N6-methyladenosine (m6A) RNA modification is …

[HTML][HTML] MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma

M Du, Y Peng, Y Li, W Sun, H Zhu, J Wu, D Zong… - Cell Death …, 2022 - nature.com
Abstract N6-Methyladenosine (m6A) modification is the most abundant RNA modification in
eukaryotic cells. IGF2BP3, a well-known m6A reader, is deregulated in many cancers, but its …

IGF2BP2 knockdown suppresses thyroid cancer progression by reducing the expression of long non-coding RNA HAGLR

L Dong, Z Geng, Z Liu, M Tao, M Pan, X Lu - Pathology-Research and …, 2021 - Elsevier
Abstract Background N6-methyladenosine (m6A), a common internal modification on RNAs,
has been found to be closely linked with RNA biosynthesis/metabolism and cancer …

Bioinformatic identification reveals a m6A-binding protein, IGF2BP2, as a novel tumor-promoting gene signature in thyroid carcinoma

Y Xie, J Xiao, Y Ying, J Liu, L Zhang, X Zeng - … -Schmiedeberg's Archives of …, 2024 - Springer
Abstract N6-methyladenosine (m6A) modification plays a crucial role in thyroid carcinoma
(THCA). Insulin-like growth factor 2 binding protein 2 (IGF2BP2) is a m6A-binding protein …

[HTML][HTML] IGF2BP2 regulates MALAT1 by serving as an N6-methyladenosine reader to promote NSCLC proliferation

L Han, G Lei, Z Chen, Y Zhang, C Huang… - Frontiers in molecular …, 2022 - frontiersin.org
Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is an important
posttranscriptional regulatory for stability and m6A modification. Here, we investigated the …

m6A writer METTL3-mediated lncRNA LINC01125 prevents the malignancy of papillary thyroid cancer

T He, H Xia, B Chen, Z Duan… - Critical Reviews™ in …, 2023 - dl.begellhouse.com
Background: Long non-coding RNA (lncRNA) LINC01125 is an anti-tumor factor in a variety
of tumors, and regulates cancer cell function. However, its function and mechanism of N6 …

[HTML][HTML] The m6A methyltransferase METTL3 drives thyroid cancer progression and lymph node metastasis by targeting LINC00894

X Zhou, L Chang, Q Liang, R Zhao, Y Xiao, Z Xu… - Cancer Cell …, 2024 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) are significant contributors to
various human malignancies. The aberrant expression of lncRNA LINC00894 has been …

Knockdown of KDM1A suppresses tumour migration and invasion by epigenetically regulating the TIMP1/MMP9 pathway in papillary thyroid cancer

WQ Zhang, W Sun, Y Qin, CH Wu, L He… - Journal of cellular …, 2019 - Wiley Online Library
Epigenetic dysregulation plays an important role in cancer. Histone demethylation is a well‐
known mechanism of epigenetic regulation that promotes or inhibits tumourigenesis in …

MiR-146b-5p Regulates the Expression of Long Noncoding RNA MALAT1 and Its Effect on the Invasion and Proliferation of Papillary Thyroid Cancer

Y Peng, X Fang, H Yao, Y Zhang… - Cancer biotherapy & …, 2021 - liebertpub.com
Background: The incidence of thyroid cancer has increased dramatically in recent decades
due, in large part, to identifications of subclinical diseases. Literature on thyroid cancer has …