Key concepts in clinical epidemiology: detecting and dealing with heterogeneity in meta-analyses
CP Cordero, AL Dans - Journal of clinical epidemiology, 2021 - Elsevier
In a meta-analysis, a question always arises. Is it worthwhile to combine estimates from
studies of different populations using various formulations of an intervention, evaluating …
studies of different populations using various formulations of an intervention, evaluating …
Heterogeneity and statistical significance in meta‐analysis: an empirical study of 125 meta‐analyses
For meta‐analysis, substantial uncertainty remains about the most appropriate statistical
methods for combining the results of separate trials. An important issue for meta‐analysis is …
methods for combining the results of separate trials. An important issue for meta‐analysis is …
Methods for exploring heterogeneity in meta-analysis
In meta-analysis, when the difference in results between studies is greater than would be
expected by chance, one needs to investigate whether the observed variation in results …
expected by chance, one needs to investigate whether the observed variation in results …
Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified
JPT Higgins - International journal of epidemiology, 2008 - academic.oup.com
It is generally accepted that meta-analyses should assess heterogeneity, which may be
defined as the presence of variation in true effect sizes underlying the different studies. This …
defined as the presence of variation in true effect sizes underlying the different studies. This …
[PDF][PDF] In a meta-analysis, the I-squared statistic does not tell us how much the effect size varies
M Borenstein - J Clin Epidemiol, 2022 - meta-analysis-workshops.com
In any meta-analysis it is important to know how the effect size varies across studies. For
example, consider a metaanalysis where the mean odds ratio is 0.50. If the odds ratio …
example, consider a metaanalysis where the mean odds ratio is 0.50. If the odds ratio …
Exploring heterogeneity in meta-analysis: is the L'Abbe plot useful?
F Song - Journal of clinical epidemiology, 1999 - Elsevier
By using a published meta-analysis as an example, this paper discusses the use of L'Abbé
plot for investigating the potential sources of heterogeneity in meta-analysis. As compared …
plot for investigating the potential sources of heterogeneity in meta-analysis. As compared …
Predicting the extent of heterogeneity in meta-analysis, using empirical data from the Cochrane Database of Systematic Reviews
RM Turner, J Davey, MJ Clarke… - International journal …, 2012 - academic.oup.com
Background Many meta-analyses contain only a small number of studies, which makes it
difficult to estimate the extent of between-study heterogeneity. Bayesian meta-analysis …
difficult to estimate the extent of between-study heterogeneity. Bayesian meta-analysis …
Combining heterogenous studies using the random-effects model is a mistake and leads to inconclusive meta-analyses
There has been a lot of skepticism over the years regarding the value of a meta-analysis.
One major area of disagreement has been the divergent findings obtained by pooled meta …
One major area of disagreement has been the divergent findings obtained by pooled meta …
Avoiding common mistakes in meta‐analysis: Understanding the distinct roles of Q, I‐squared, tau‐squared, and the prediction interval in reporting heterogeneity
M Borenstein - Research Synthesis Methods, 2024 - Wiley Online Library
In any meta‐analysis, it is critically important to report the dispersion in effects as well as the
mean effect. If an intervention has a moderate clinical impact on average we also need to …
mean effect. If an intervention has a moderate clinical impact on average we also need to …
Performance of between-study heterogeneity measures in the Cochrane library
The growth in comparative effectiveness research and evidence-based medicine has
increased attention to systematic reviews and meta-analyses. Meta-analysis synthesizes …
increased attention to systematic reviews and meta-analyses. Meta-analysis synthesizes …