Epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most
common metastatic skin cancer with high mortality rates in the advanced stage. Chronic …

There is increasing evidence that the complement system is activated in various cancer
tissues. Besides being involved in innate immunity against pathogens, the complement …

The involvement of complement-activation products in promoting tumor growth has not yet
been recognized. Here we show that the generation of complement C5a in a tumor …

Preclinical studies demonstrated that complement promotes tumor growth. Therefore, we
sought to determine the best target for complement-based therapy among common human …

The complement system is a crucial mediator of the innate immune response, contributing to
cell homeostasis, tissue development, and repair, reproduction, and cross-talk with other …

With increasing evidence that complement activation significantly contributes to the
pathogenesis of a large number of inflammatory diseases, strategies that interfere with its …

The complement system is a powerful tool of the innate immune system to eradicate
pathogens. Both in vitro and in vivo evidence indicates that therapeutic anti-tumor …

Membrane-bound complement inhibitors protect host cells from inadvertent complement
attack, and complement inhibitors are often up-regulated on tumors, possibly representing a …

Complement is traditionally thought of as a proinflammatory effector mechanism of antitumor
immunity. However, complement is also important for effective clearance of apoptotic cells …

It has long been understood that the control and surveillance of tumors within the body
involves an intricate dance between the adaptive and innate immune systems. At the center …