Complement is recognized as a key player in a wide range of normal as well as disease-
related immune, developmental and homeostatic processes. Knowledge of complement …

The complement system is an essential component of innate immunity that has been more
recently recognized as an unexpected player in various pathological states. These include …

The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

SUMMARY CD59, decay accelerating factor (DAF) and membrane cofactor protein (MCP)
are widely expressed cell surface glycoproteins that protect host cells from the effects of …

Promoting complement (C) activation may enhance immunological mechanisms of anti-
tumor Abs for tumor destruction. However, C activation components, such as C5a, trigger …

Clear-cell renal cell carcinoma (ccRCC) possesses an unmet medical need, particularly at
the metastatic stage, when surgery is ineffective. Complement is a key factor in tissue …

Anti-tumor monoclonal antibody therapy represents one of the earliest targeted therapy in
clinical cancer care and has achieved a great clinical promise. Complement activation …

The complement system is a powerful effector arm of innate immunity that typically confers
protection from microbial intruders and accumulating debris. In many clinical situations …

For decades, the complement system, the central pillar of innate immune response, was
recognized as a protective mechanism against cancer cells and the manipulation of …

Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …