The role of renal cortical and medullary hypoxia in the development of acute kidney injury is
controversial, partly due to a lack of techniques for the long-term measurement of intrarenal …

Vasoactive agents are used in critical care to optimize circulatory function, but their effects
on renal tissue oxygenation in the absence of anesthesia remain largely unknown …

A relative deficiency in kidney oxygenation, ie, renal hypoxia, may contribute to the initiation
and progression of acute and chronic kidney disease. A critical barrier to investigate this is …

Previous studies have suggested a link between renal metabolism and local kidney
hemodynamics to prevent potential hypoxic injury of particularly vulnerable nephron …

Previous studies of intrarenal perfusion and tissue oxygenation have produced a wide range
of results and have not matched tissue oxygen tension (tPo2) with concurrent changes in …

Tissue hypoxia has been demonstrated, in both the renal cortex and medulla, during the
acute phase of reperfusion after ischemia induced by occlusion of the aorta upstream from …

We studied the responses of total renal blood flow (RBF) and renal medullary blood flow
(RMBF) to changes in renal perfusion pressure (RPP) within and below the range of renal …

METHODS Twenty-five experiments were performed on 15 unanesthetized male New
Zealand rabbits with an average body weight of 3 kg (range 2.5-3.5 kg). Tissue 02 was …

Expansion of extracellular fluid volume with crystalloid solutions is a common medical
intervention, but its effects on renal cortical and medullary oxygenation are poorly …

The precise roles of hypoxia in the initiation and progression of kidney disease remain
unresolved. A major technical limitation has been the absence of methods allowing long …