Background: Less than 50% of patients experience sufficient pain relief with current drug
therapy for neuropathic pain. Minocycline shows promising results in rodent models of …

Objective Minocycline is known to reduce microglial activation, suggesting that it may reduce
neuropathic pain. We reviewed studies in humans that evaluated the effectiveness of …

Recent understanding of the neuron–glia communication shed light on an important role of
microglia to develop neuropathic pain The analgesic effect of minocycline on neuropathic …

Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …

Background and Objectives Minocycline is a second-generation tetracycline with multiple
biological effects, including inhibition of microglial activation. Recently, microglial activation …

Minocycline strongly inhibits microglial activation, which contributes to central sensitization,
a major mechanism underlying chronic pain development. We hypothesized that the …

Neuropathic pain is an intractable clinical problem, affecting millions of people worldwide.
Preemptive administration of minocycline has been confirmed useful for treating neuropathic …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …

Background: Evidence indicates that neuropathic pain pathogenesis is not confined to
changes in the activity of neuronal systems but involves interactions between neurons …

The present study investigates the analgesic effect of minocycline, a semi-synthetic
tetracycline antibiotic, in a rat model of inflammation-induced visceral pain. Inflammation …