As part of a program to develop drugs which will delay or prevent cancer in humans, the
Chemoprevention Branch, National Cancer Institute, National Institutes of Health, is …

Clinical chemoprevention trials of more than 30 agents and agent combinations are now in
progress or being planned. The most advanced agents are well known and are in large …

Chemopreventive agents are natural or synthetic agents administered to prevent, inhibit or
reverse one or more of the stages of carcinogenesis. Natural agents include vitamins …

Chemoprevention drug development has the goal of identifying safe and effective
chemopreventive agents for clinical use. Several distinctive strategies are pursued in …

A new direction for cancer prevention and control is chemoprevention, defined as the use of
specific natural and synthetic chemical agents to reverse or suppress carcinogenesis and …

The clinical development of cancer chemoprevention agents is similar to that of cytotoxic
agents. On the basis of promising preclinical studies, agents with potential efficacy are …

PURPOSE To review the most important recent advances in clinical trials and biologic
studies within the growing field of chemoprevention. METHODS The most critical methods …

The incidence and mortality rates for most of the common forms of cancer are still
unacceptably high. This stark fact in itself is a strong argument for further research, both …

The fundamental goal of the National Cancer Institute's (NCI) chemoprevention drug
development program is the identification of safe and effective agents for the prevention of …

The ultimate toxic effect of many natural environmental pollutants as well as synthetic
chemicals is the development of cancer, which next only to heart diseases, is the second …