Fabrication of carboxymethylcellulose-gelatin dissolving microneedle patch for pain-free, efficient, and controlled transdermal delivery of insulin

BA Jana, RA Osmani, S Jaiswal, R Banerjee… - Journal of …, 2023 - Springer
Purpose Dissolving microneedle patches are attracting attention as they are associated with
improved patient compliance and safety. Methods This study fabricated dissolving …

Innovative freeze-drying technique in the fabrication of dissolving microneedle patch: Enhancing transdermal drug delivery efficiency

T Su, Z Tang, J Hu, Y Zhu, T Shen - Drug Delivery and Translational …, 2024 - Springer
Microneedle patch (MNP) has become a hot research topic in the field of transdermal drug
delivery due to its ability to overcome the stratum corneum barrier. Among the various types …

Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice

IC Lee, WM Lin, JC Shu, SW Tsai… - … research Part A, 2017 - Wiley Online Library
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …

Dissolving microneedle rollers for rapid transdermal drug delivery

XP Zhang, BL Zhang, BZ Chen, ZQ Zhao… - Drug Delivery and …, 2022 - Springer
Dissolving microneedle patch (DMNP) is a minimally invasive and painless self-
administration device. However, due to skin deformation, it is difficult to apply it on the large …

Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity

S Kim, H Yang, J Eum, Y Ma, SF Lahiji, H Jung - Biomaterials, 2020 - Elsevier
Recently, numerous transdermal drug delivery systems have been developed for safe and
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …

[HTML][HTML] Dissolving polymer microneedles for transdermal delivery of insulin

N Zhang, X Zhou, L Liu, L Zhao, H Xie… - Frontiers in …, 2021 - frontiersin.org
It's of great significance to develop insulin-loaded dissolving microneedles (MNs) which are
fabricated with various methods and materials for transdermal delivery of insulin to …

[HTML][HTML] Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications

CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …

Practicality of non-invasive glucagon-loaded dissolving microneedle for life-saving treatment of severe hypoglycemia in a diabetic rat model

X Wang, Y Ma, X Qi, X Ruan, D Cao, F Zhao - International Journal of …, 2023 - Elsevier
The development of dissolving microneedles (DMNs) has brought light to the transdermal
delivery of biomolecules that are released into the skin through the rapid dissolution of the …

Novel lyophilized hydrogel patches for convenient and effective administration of microneedle-mediated insulin delivery

Y Qiu, G Qin, S Zhang, Y Wu, B Xu, Y Gao - International journal of …, 2012 - Elsevier
A lyophilized hydrogel patch system was developed for microneedle-mediated insulin
delivery. The matrix of Cross-linked poly (acrylamide-co-acrylic acid) were synthesized by …

Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats

MH Ling, MC Chen - Acta biomaterialia, 2013 - Elsevier
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …