Immune checkpoint receptors are crucial molecules for fine-tuning immune responses.
Checkpoint signaling dampens T cell activation to avoid autoimmunity and the destructive …

Immune responses are regulated by an exquisite system of checks and balances that
enable effective protective immunity and tolerance. A number of immunological checkpoints …

The immune system recognizes and is poised to eliminate cancer but is held in check by
inhibitory receptors and ligands. These immune checkpoint pathways, which normally …

The clinical success of immune checkpoint inhibitors has highlighted the central role of the
immune system in cancer control. Immune checkpoint inhibitors can reinvigorate anti-cancer …

The immune system is the core defense against cancer development and progression.
Failure of the immune system to recognize and eliminate malignant cells plays an important …

Among the main promising systems to triggering therapeutic antitumor immunity is the
blockade of immune checkpoints. Immune checkpoint pathways regulate the control and …

Background The discovery of immune checkpoint proteins and the mechanisms by which
cancer cells utilize them to evade the immune system has transformed our approach to …

Although T lymphocytes have long been appreciated for their role in the immunosurveillance
of cancer, it has been the realization that cancer cells may ultimately escape a response …

The immune system frequently comprises immunological checkpoints. They serve as a
barrier to keep the immune system from overreacting and damaging cells that are robust …

Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance
antitumor immune responses, has led to important clinical advances and provided a new …