The endoplasmic reticulum (ER) is the cellular site of newly synthesized secretory and
membrane proteins. Such proteins must be properly folded and posttranslationally modified …

The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and
transmembrane proteins are assembled and folded into their correct tertiary structures …

Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the
unfolded protein response (UPR), a signaling pathway with both adaptive and apoptotic …

The endoplasmic reticulum (ER) is recognized primarily as the site of synthesis and folding
of secreted and membrane‐bound proteins. The ER provides stringent quality control …

The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane
proteins are synthesized and folded. Correctly folded proteins exit the ER and are …

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of
homeostasis causes stress. In this review I summarize how perturbation of three major …

The endoplasmic reticulum (ER) is a highly dynamic organelle of fundamental importance
present in all eukaryotic cells. The majority of synthesized structural and secreted proteins …

Increased demand on the protein folding capacity of the endoplasmic reticulum (ER)
engages an adaptive reaction known as the unfolded protein response (UPR). The UPR …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

The efficient functioning of the endoplasmic reticulum (ER) is essential for most cellular
activities and survival. Conditions that interfere with ER function lead to the accumulation …