Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers
FG Abdulrahman, HS Abulkhair, HS El Saeed… - Bioorganic …, 2024 - Elsevier
As regards to the structural analysis and optimization of diverse potential EGFR inhibitors,
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …
[HTML][HTML] Novel benzimidazole derivatives as anti-cervical cancer agents of potential multi-targeting kinase inhibitory activity
EA Abd El-Meguid, EMM El-Deen, MA Nael… - Arabian Journal of …, 2020 - Elsevier
Abstract Multi-target EGFR, HER2, VEGFR-2 and PDGFR is an improved strategy for the
treatment of solid tumors. This work deals with synthesis of an array of new 6-benzoyl …
treatment of solid tumors. This work deals with synthesis of an array of new 6-benzoyl …
EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid …
One of the helpful ways to improve the effectiveness of anticancer agents and weaken drug
resistance is to use hybrid molecules. therefore, the current study intended to introduce 20 …
resistance is to use hybrid molecules. therefore, the current study intended to introduce 20 …
Arylidenes of Quinolin-2-one scaffold as Erlotinib analogues with activities against leukemia through inhibition of EGFR TK/STAT-3 pathways
MAI Elbastawesy, M Ramadan, YAMM El-Shaier… - Bioorganic …, 2020 - Elsevier
A new series of 6-substiuted-4-(2-(4-substituted-benzylidene) hydrazinyl) quinolin-2 (1H)-
one derivatives have been designed and synthesized. The structure of the synthesized …
one derivatives have been designed and synthesized. The structure of the synthesized …
New Thiazolyl-Pyrazoline derivatives as potential dual EGFR/HER2 inhibitors: design, synthesis, anticancer activity evaluation and in silico study
A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …
have been designed and synthesized through the combination of thiazole and pyrazoline …
Dual kinase inhibition of EGFR/HER2: design, synthesis and molecular docking of thiazolylpyrazolyl‐based aminoquinoline derivatives as anticancer agents
RZ Batran, WA El‐Kashak, SM El‐Daly… - …, 2021 - Wiley Online Library
Two new series of aminoquinoline based derivatives (thiazolyl pyrazolines and pyrazolyl
thiazolidinones) were designed and synthesized. The in vitro antiporliferative activity of the …
thiazolidinones) were designed and synthesized. The in vitro antiporliferative activity of the …
Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies
Novel hybrids of pyridazine-pyrazoline were synthesized aiming to develop new
antiproliferative candidates. All compounds were submitted to the National Cancer Institute …
antiproliferative candidates. All compounds were submitted to the National Cancer Institute …
Synthesis, anticancer activity and molecular modeling studies of 1, 2, 4-triazole derivatives as EGFR inhibitors
HAM El-Sherief, BGM Youssif, SNA Bukhari… - European journal of …, 2018 - Elsevier
A series of novel compounds carrying 1, 2, 4-triazole scaffold were prepared and evaluated
for their antiproliferative activities against NCI 60 cell line. Compounds 10 (a, c), 11 (ad), and …
for their antiproliferative activities against NCI 60 cell line. Compounds 10 (a, c), 11 (ad), and …
Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors
Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAFV600E inhibitors have
been developed. The target compounds were synthesized and tested in vitro against four …
been developed. The target compounds were synthesized and tested in vitro against four …
Antiproliferative activity, enzymatic inhibition and apoptosis-promoting effects of benzoxazole-based hybrids on human breast cancer cells
AMME Omar, OM AboulWafa, ME Amr… - Bioorganic …, 2021 - Elsevier
Abstract New benzoxazole derivatives containing 1, 3, 4-oxadiazole, 1, 2, 4-triazole or
triazolothiadiazine rings were synthesized and screened for their in vitro antiproliferative …
triazolothiadiazine rings were synthesized and screened for their in vitro antiproliferative …