Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies
Novel hybrids of pyridazine-pyrazoline were synthesized aiming to develop new
antiproliferative candidates. All compounds were submitted to the National Cancer Institute …
antiproliferative candidates. All compounds were submitted to the National Cancer Institute …
Antiproliferative activity, enzymatic inhibition and apoptosis-promoting effects of benzoxazole-based hybrids on human breast cancer cells
AMME Omar, OM AboulWafa, ME Amr… - Bioorganic …, 2021 - Elsevier
Abstract New benzoxazole derivatives containing 1, 3, 4-oxadiazole, 1, 2, 4-triazole or
triazolothiadiazine rings were synthesized and screened for their in vitro antiproliferative …
triazolothiadiazine rings were synthesized and screened for their in vitro antiproliferative …
Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1, 2, 3-triazole fragment that mimic quinazoline epidermal growth factor receptor …
N Rezki, MA Almehmadi, S Ihmaid, AM Shehata… - Bioorganic …, 2020 - Elsevier
A series of benzothiazole/isatin linked to 1, 2, 3-triazole moiety and terminal sulpha drugs 5a-
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …
Design, synthesis and anticancer evaluation of thieno [2, 3-d] pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers
Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …
kinase family is one of the most important targets in current cancer therapy regimens. In this …
New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity
New series of thiazole and imidazo [2, 1-b] thiazole derivatives were synthesized and tested
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …
Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3‐d]pyrimidine derivatives as EGFR inhibitors
Abstract New series of 20 thieno [2, 3‐d] pyrimidine derivatives have been synthesized. The
National Cancer Institute evaluated all the newly synthesized compounds for their …
National Cancer Institute evaluated all the newly synthesized compounds for their …
Synthesis and anti-proliferative activity of some new quinoline based 4, 5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors
Abstract Quinoline derivatives 2, 3, quinolinyl based pyrazolines 4a, b, 5 and quinolinyl
pyrazolinyl thiazole hybrids 6a-d, 7a-c and 8a-d were synthesized and screened for their …
pyrazolinyl thiazole hybrids 6a-d, 7a-c and 8a-d were synthesized and screened for their …
Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M
AA Gaber, M Sobhy, A Turky… - Journal of Enzyme …, 2022 - Taylor & Francis
Abstract New 1 H-pyrazolo [3, 4-d] pyrimidine derivatives were designed and synthesised to
act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives …
act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives …
Structure-based design, synthesis and antiproliferative action of new quinazoline-4-one/chalcone hybrids as EGFR inhibitors
A new series of quinazoline-4-one/chalcone hybrids, 7–26, was synthesized in this study as
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
Design, synthesis and biological evaluation of benzohydrazide derivatives containing dihydropyrazoles as potential EGFR kinase inhibitors
HC Wang, XQ Yan, TL Yan, HX Li, ZC Wang, HL Zhu - Molecules, 2016 - mdpi.com
A series of novel benzohydrazide derivatives containing dihydropyrazoles have been
synthesized as potential epidermal growth factor receptor (EGFR) kinase inhibitors and their …
synthesized as potential epidermal growth factor receptor (EGFR) kinase inhibitors and their …