Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4 (5H)-ones as potential apoptotic inducers targeting wild …
A novel series of ethylidenehydrazineylthiazol-4 (5H)-ones were synthesized using various
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors
KM Qiu, HH Wang, LM Wang, Y Luo, XH Yang… - Bioorganic & medicinal …, 2012 - Elsevier
A series of pyrazolyl-thiazolinone derivatives (E1–E36) have been designed and
synthesized and their biological activities were also evaluated as potential EGFR and HER …
synthesized and their biological activities were also evaluated as potential EGFR and HER …
Dual EGFR/HER2 inhibitors and apoptosis inducers: New benzo [g] quinazoline derivatives bearing benzenesulfonamide as anticancer and radiosensitizers
MM Ghorab, MS Alsaid, AM Soliman - Bioorganic Chemistry, 2018 - Elsevier
Dual targeting of EGFR and HER2 is a proven anticancer strategy for the treatment of solid
tumors. An array of new N-substituted-2-(4-oxo-3-(4-sulfamoylphenyl)-3, 4-dihydrobenzo [g] …
tumors. An array of new N-substituted-2-(4-oxo-3-(4-sulfamoylphenyl)-3, 4-dihydrobenzo [g] …
New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation
New series of isoxazole derivatives were synthesized and evaluated for in vitro antitumor
activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a …
activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a …
Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors
PC Lv, CF Zhou, J Chen, PG Liu, KR Wang… - Bioorganic & medicinal …, 2010 - Elsevier
Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …
6, 7-Dimorpholinoalkoxy quinazoline derivatives as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells
Y Zhang, L Chen, H Xu, X Li, L Zhao, W Wang… - European Journal of …, 2018 - Elsevier
Abstract A series of novel 6, 7-dimorpholinoalkoxy quinazoline derivatives was designed,
synthesized and evaluated as potent EGFR inhibitors. Most of synthesized derivatives …
synthesized and evaluated as potent EGFR inhibitors. Most of synthesized derivatives …
New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies
IMM Othman, ZM Alamshany, NY Tashkandi… - Bioorganic …, 2021 - Elsevier
This study was focused on the synthesis of new pyrimidines 4a, b, 5a, b and pyrazoles 6a, b
as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) …
as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) …
Synthesis and in vitro anticancer evaluation of some fused indazoles, quinazolines and quinolines as potential EGFR inhibitors
EA Abdelsalam, WA Zaghary, KM Amin… - Bioorganic …, 2019 - Elsevier
Abstract derivatives of benzo [g] indazole 5a, b, benzo [h] quinazoline 7, 12a-c, 13a-c and
15a-c and benzo [h] quinoline 17a-c and 19a-c were synthesized from 6-methoxy-3, 4 …
15a-c and benzo [h] quinoline 17a-c and 19a-c were synthesized from 6-methoxy-3, 4 …
Dual EGFR/VEGFR2 inhibitors and apoptosis inducers: synthesis and antitumor activity of novel pyrazoline derivatives
Novel derivatives of the pyrazoline scaffold were synthesized and investigated for their
cytotoxicity against prostate (PC‐3), hepatocellular (HepG2), and breast (MDA‐MB‐231) …
cytotoxicity against prostate (PC‐3), hepatocellular (HepG2), and breast (MDA‐MB‐231) …
Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies
MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …