Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers
NH Amin, MT Elsaadi, SS Zaki, HM Abdel-Rahman - Bioorganic Chemistry, 2020 - Elsevier
Herein, we report the synthesis of novel 2-substituted styrylquinazolines conjugated with
aniline or sulfonamide moieties, anticipated to act as potent anticancer therapeutic agents …
aniline or sulfonamide moieties, anticipated to act as potent anticancer therapeutic agents …
Design, synthesis and anticancer evaluation of 1H-pyrazolo [3, 4-d] pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers
In our attempt to develop effective EGFR-TKIs, two series of 1H-pyrazolo [3, 4-d] pyrimidine
derivatives were designed and synthesized. All the newly synthesized compounds were …
derivatives were designed and synthesized. All the newly synthesized compounds were …
Novel pyridine-thiazolidinone-triazole hybrid glycosides targeting EGFR and CDK-2: Design, synthesis, anticancer evaluation, and molecular docking simulation
AF Kassem, MA Omar, ES Nossier, HM Awad… - Journal of Molecular …, 2023 - Elsevier
The observed toxicity of newly designed anticancer drugs is considered as an impediment
challenging phenomenon of intense concern arising from diversity in drug targets and the …
challenging phenomenon of intense concern arising from diversity in drug targets and the …
Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
Abstract Nineteen new quinazolin-4 (3 H)-one derivatives 3a–g and 6a–l were designed
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …
Synthesis and biological evaluation of novel 2, 4′-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase …
SM Abou-Seri - European journal of medicinal chemistry, 2010 - Elsevier
Four new series of 2, 4′-bis diphenylamine hydrazones 14, 2, 4′-bis aminothiadiazole 16,
2, 4′-bis mercaptotriazole 17–18 and 2, 4′-bis mercapto-oxadiazole diphenylamine …
2, 4′-bis mercaptotriazole 17–18 and 2, 4′-bis mercapto-oxadiazole diphenylamine …
Benzoxazole-appended piperidine derivatives as novel anticancer candidates against breast cancer
Novel series of benzoxazole-appended piperidine derivatives were planned, synthesized
and screened against two breast cancer cell lines. Considerable antiproliferative activity was …
and screened against two breast cancer cell lines. Considerable antiproliferative activity was …
Isatin-Schiff's base and chalcone hybrids as chemically apoptotic inducers and EGFR inhibitors; design, synthesis, anti-proliferative activities and in silico evaluation
EA Fayed, RRE Eldin, ABM Mehany… - Journal of Molecular …, 2021 - Elsevier
Isatin derivatives have been found to possess anti-proliferative effects against different
human cancer cell lines. A series of isatin-Schiff's base and chalcone were synthesized and …
human cancer cell lines. A series of isatin-Schiff's base and chalcone were synthesized and …
Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors
Two series of quinazoline derivatives bearing aryl semicarbazone scaffolds (9a–o and 10a–
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic …
New EGFR inhibitor series of fifteen 5-chloro-3-hydroxymethyl-indole-2-carboxamide
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …