Design, synthesis and mechanistic studies of novel imidazo [1, 2-a] pyridines as anticancer agents
Herein, the design, synthesis and mechanistic study of five series of imidazo [1, 2-a]
pyridines 8a-d, 9a-f, 11a-c, 12a-d and 14a-d as anticancer agents were discussed. The …
pyridines 8a-d, 9a-f, 11a-c, 12a-d and 14a-d as anticancer agents were discussed. The …
Modified pyrido [2, 3-d] pyrimidin-4 (3H)-one derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, and anti-cancer evaluation
ES Nossier, RA Alasfoury, M Hagras… - Journal of Molecular …, 2022 - Elsevier
This study reports design and synthesis of thirteen pyrido [2, 3-d] pyrimidin-4 (3H)-one
derivatives as EGFR inhibitors. The antiproliferation activities were tested for all compounds …
derivatives as EGFR inhibitors. The antiproliferation activities were tested for all compounds …
Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti …
WAA Fadaly, MTM Nemr, NM Kahk - Bioorganic Chemistry, 2024 - Elsevier
A novel series of pyrazole derivatives with urea/thiourea scaffolds 16a-l as hybrid
sorafenib/erlotinib/celecoxib analogs was designed, synthesized and tested for its VEGFR-2 …
sorafenib/erlotinib/celecoxib analogs was designed, synthesized and tested for its VEGFR-2 …
[HTML][HTML] Design and synthesis of some novel pyridothienopyrimidine derivatives and their biological evaluation as antimicrobial and anticancer agents targeting EGFR …
EMM El-Deen, MM Anwar, AA Abd El-Gwaad… - Arabian Journal of …, 2022 - Elsevier
A new series of pyridothienopyrimidine derivatives was designed and evaluated as
antimicrobial and anticancer agents. The target compounds were synthesized starting with 3 …
antimicrobial and anticancer agents. The target compounds were synthesized starting with 3 …
Benzoxazole derivatives as new generation of anti-breast cancer agents
AMME Omar, OM AboulWafa, MS El-Shoukrofy… - Bioorganic …, 2020 - Elsevier
New 2-substituted benzoxazole derivatives were synthesized and screened for their in vitro
anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d …
anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d …
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer …
New acetamide (IV ae) and 1, 3-thiazolidinone derivatives (VII ae) were designed,
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
Design, synthesis and biological activities of novel oxazolo [4, 5-g] quinazolin-2 (1H)-one derivatives as EGFR inhibitors
S Yin, L Zhou, J Lin, L Xue, C Zhang - European Journal of Medicinal …, 2015 - Elsevier
Abstract A series of oxazolo [4, 5-g] quinazolin-2 (1H)-one derivatives employing Erlotinib as
lead compound were synthesized and evaluated for their EGFR inhibition activity. These …
lead compound were synthesized and evaluated for their EGFR inhibition activity. These …
Synthesis, biological evaluation and molecular modeling study of [1, 2, 4]-Triazolo [4, 3-c] quinazolines: New class of EGFR-TK inhibitors
Abstract New series of triazolo [4, 3-c] quinazolines were designed, synthesized and their
structures were elucidated using different spectroscopic techniques. They were evaluated …
structures were elucidated using different spectroscopic techniques. They were evaluated …
Synthesis, molecular modeling and biological evaluation of cinnamic acid derivatives with pyrazole moieties as novel anticancer agents
WM Zhang, M Xing, TT Zhao, YJ Ren, XH Yang… - RSC …, 2014 - pubs.rsc.org
A series of pyrazole derivatives (1e–30e) has been designed and synthesized, and their
biological activities were evaluated for EGFR and HER-2 inhibition and tumor cell …
biological activities were evaluated for EGFR and HER-2 inhibition and tumor cell …
Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
Lung cancer is one of the most common cancer types of cancer with the highest mortality
rates. However, while epidermal growth factor receptor (EGFR) is an important parameter for …
rates. However, while epidermal growth factor receptor (EGFR) is an important parameter for …