Mesenchymal stem cells-derived exosomes alleviate acute lung injury by inhibiting alveolar macrophage pyroptosis

P Liu, S Yang, X Shao, C Li, Z Wang… - Stem Cells …, 2024 - academic.oup.com
Acute lung injury (ALI) is an important pathological process of acute respiratory distress
syndrome, yet there are limited therapies for its treatment. Mesenchymal stem cells-derived …

BMSC‐derived exosomes ameliorate LPS‐induced acute lung injury by miR‐384‐5p‐controlled alveolar macrophage autophagy

X Liu, C Gao, Y Wang, L Niu, S Jiang… - Oxidative Medicine and …, 2021 - Wiley Online Library
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common critical
diseases. Bone marrow mesenchymal stem cell (BMSC) transplantation is previously shown …

Mitigation of sepsis-induced acute lung injury by BMSC-derived exosomal miR-125b-5p through STAT3-mediated suppression of macrophage pyroptosis

Y Tao, X Xu, B Yang, H Zhao, Y Li - International Journal of …, 2023 - Taylor & Francis
Introduction Sepsis is a syndrome characterized by high morbidity and mortality rates. One
of its most severe complications is acute lung injury, which exhibits a multitude of clinical …

[HTML][HTML] Mesenchymal stem cell exosomes reverse acute lung injury through Nrf-2/ARE and NF-κB signaling pathways

J Li, X Deng, X Ji, X Shi, Z Ying, K Shen, D Xu, Z Cheng - PeerJ, 2020 - peerj.com
Acute lung injury (ALI) is associated with histopathological diffuse alveolar damage. The
potential role of mesenchymal stem cells (MSCs) in the treatment of various clinical …

Exosomes Derived from hucMSCs Primed with IFN-γ Suppress the NF-κB Signal Pathway in LPS-Induced ALI by Modulating the miR-199b-5p/AFTPH Axis

C Wang, Y Yang, C Jiang, C Xi, Y Yin, H Wu… - Cell Biochemistry and …, 2024 - Springer
Exosomes (exos) are primarily responsible for the process of mesenchymal stem cells
(MSCs) treatment for acute lung injury (ALI), but the mechanism remains unclear, particularly …

Exosomal miR-127-5p from BMSCs alleviated sepsis-related acute lung injury by inhibiting neutrophil extracellular trap formation

XL Zheng, WJ Gu, F Zhang, FZ Zhao, LZ Li… - International …, 2023 - Elsevier
Neutrophil extracellular traps (NETs) play an important role in sepsis-related acute lung
injury (ALI). Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes and miRNA …

Umbilical cord MSC‐derived exosomes improve alveolar macrophage function and reduce LPS‐induced acute lung injury

E Cui, L Lv, B Wang, L Li, H Lu, F Hua… - Journal of Cellular …, 2024 - Wiley Online Library
Acute lung injury (ALI) is a severe condition that can progress to acute respiratory distress
syndrome (ARDS), with a high mortality rate. Currently, no specific and compelling drug …

[HTML][HTML] AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

L Xia, C Zhang, N Lv, Z Liang, T Ma, H Cheng, Y Xia… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be
associated with pathogenesis of ALI (acute lung injury). Exosomes from adipose-derived …

Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3

X Yi, X Wei, H Lv, Y An, L Li, P Lu, Y Yang… - Experimental cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) have been widely documented for their potential role in the
treatment of various clinical disorders, including acute lung injury (ALI). ALI represents a …

Stem cell derived exosomes-based therapy for acute lung injury and acute respiratory distress syndrome: a novel therapeutic strategy

B Xu, S Chen, M Liu, C Gan, J Li, G Guo - Life Sciences, 2020 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical
disease which can be caused by multiple pathological factors in clinic. However, feasible …