Background: Epidemiology of patients with worsening heart failure and reduced ejection
fraction (HFrEF) in the real-world setting is not well described. Objectives: The purpose of …

Heart failure is a global public health problem that affects more than 26 million people
worldwide. The global burden of heart failure is growing and is expected to increase …

Background: Guidelines strongly recommend patients with heart failure with reduced
ejection fraction (HFrEF) be treated with multiple medications proven to improve clinical …

Background—Randomized trials have demonstrated the efficacy of several new therapies
for heart failure (HF) with reduced ejection fraction over the preceding 2 decades. This study …

Heart failure patients are classified by ejection fraction (EF) into distinct groups: heart failure
with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction …

Introduction A worsening heart failure event (WHFE) is defined as progressively escalating
heart failure signs/symptoms requiring intravenous diuretic treatment or hospitalization. No …

The advent of newly available medical therapies for heart failure with reduced ejection
fraction (HFrEF) has resulted in many potential therapeutic combinations, increasing …

Background: Guidelines recommend that patients with heart failure with reduced ejection
fraction (HFrEF) have medical therapy titrated to target doses derived from clinical trials, as …

Background For patients hospitalized for heart failure with reduced ejection fraction (HFrEF),
guidelines recommend optimization of medical therapy prior to discharge. The degree to …

Importance Worldwide, the burden of heart failure has increased to an estimated 23 million
people, and approximately 50% of cases are HF with reduced ejection fraction (HFrEF) …