Volume and chemical characteristics of meals in the gut have been proposed to generate
vagal afferent signals that mediate the negative feedback control of ingestion and gastric …

To assess nutrient sensitivity in a population of gastric load-sensitive vagal afferents, their
neurophysiological activity was examined in anesthetized rats with inflated pyloric cuffs after …

The arrival of nutrients in the gastrointestinal tract suppresses intake. To specify the neural
pathways and receptor locations of this feedback, we examined the effects of intraduodenal …

We have established a method to investigate the range of mechanical, nutrient chemical and
peptidergic meal-related stimuli that may generate vagal afferent neurophysiological signals …

BACKGROUND & AIMS: The gut-brain axis, which transmits nutrient information from the
gastrointestinal tract to the brain, is important for the detection of dietary nutrients. We used …

It is assumed that in humans pancreatic and gastrointestinal motor responses to a meal are
coordinated and regulated mainly by duodenal nutrient exposure. On the other hand, there …

Duodenal infusions of macronutrients inhibit sham and normal feeding. Neural substrates of
this response were studied by infusing glucose, linoleic acid, an amino acid mixture, saline …

Mechanical and chemical stimulation of the gastrointestinal mucosa exerts negative and
positive feedback regulation of secretory and motor function of the gastrointestinal tract. The …

The ability of intraintestinal nutrient infusions to suppress sham feeding was examined in
intact rats and in rats with total subdiaphragmatic vagal transections. Vagotomy abolished …

We have previously described a negative feedback loop that inhibits duodenal motility when
nutrients are infused into the ileum and colon. In the present study, we examined the role of …