Introduction The spike (S) of SARS coronavirus 2 (SARS-CoV-2) engages angiotensin-
converting enzyme 2 (ACE2) on a host cell to trigger viral-cell membrane fusion and …

The recent global pandemic was a spillover from the SARS-CoV-2 virus. Viral entry involves
the receptor binding domain (RBD) of the viral spike protein interacting with the protease …

Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19
pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to …

The SARS-CoV-2 spike protein binds to the human angiotensin-converting enzyme 2
(ACE2) receptor via receptor binding domain (RBD) to enter into the cell and inhibiting this …

Highlights•Mutation informatics study on RBD of SARS-CoV-2 variants.•Discussion of small
molecules targeting the RBD/ACE2 interface.•Ideation to design novel inhibitors against wild …

The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …

Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective
approaches to contain the pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome …

The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance
to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic …

The coronavirus disease-2019 (COVID-19) pandemic, caused by the pathogen severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), started in China during late 2019 and …

The interaction between the receptor-binding domain (RBD) of the SARS-CoV-2 spike
glycoprotein and the ACE2 enzyme is believed to be the entry point of the virus into various …