Whereas some sphingolipids such as sphingoid bases and ceramide can mediate and
induce cell killing, other sphingolipids such as sphingosine 1-phosphate promote cell …

Sphingolipid metabolites play critical functions in the regulation of a number of fundamental
biological processes including cancer. Whereas ceramide and sphingosine mediate and …

In this chapter, roles of bioactive sphingolipids in the regulation of cancer pathogenesis and
therapy will be reviewed. Sphingolipids have emerged as bioeffector molecules, which …

Sphingolipids constitute a broad class of compounds with many biological functions. The
sphingolipid metabolites ceramide and sphingosine are potent apoptosis inducers and …

Sphingolipid metabolites are critical to the regulation of a number of fundamental biological
processes including cancer. Whereas ceramide and sphingosine mediate and trigger …

Sphingolipid metabolites have become recognized for their participation in cell functions
and signaling events that control a wide array of cellular activities. Two main sphingolipids …

C eramide and sphingosine-1-phosphate are related sphingolipid metabolites that can be
generated through a de novo biosynthetic route or derived from the recycling of membrane …

Sphingolipids are known to play important roles in the regulation of cell proliferation,
response to chemotherapeutic agents, and/or prevention of cancer. Recently, significant …

Sphingolipids represent an important class of bioactive signaling lipids which have key roles
in numerous cellular processes. Over the last few decades, the levels of bioactive …

The sphingolipids ceramide, sphingosine and sphingosine 1-phosphate have emerged as
important signaling molecules that regulate a number of important cellular processes …