Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice
G Heinrich, S Ghosh, AM DeAngelis… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance …
(CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance …
Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism
AM DeAngelis, G Heinrich, T Dai, TA Bowman… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Liver-specific inactivation of carcinoembryonic antigen-related cell adhesion
molecule 1 (CEACAM1) by a dominant-negative transgene (l-SACC1 mice) impaired insulin …
molecule 1 (CEACAM1) by a dominant-negative transgene (l-SACC1 mice) impaired insulin …
Reduced hepatic carcinoembryonic antigen-related cell adhesion molecule 1 level in obesity
G Heinrich, HT Muturi, K Rezaei, QY Al-Share… - Frontiers in …, 2017 - frontiersin.org
Impairment of insulin clearance is being increasingly recognized as a critical step in the
development of insulin resistance and metabolic disease. The carcinoembryonic antigen …
development of insulin resistance and metabolic disease. The carcinoembryonic antigen …
Forced hepatic overexpression of CEACAM1 curtails diet-induced insulin resistance
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …
Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice
L Russo, HT Muturi, HE Ghadieh, SS Ghanem… - Diabetologia, 2017 - Springer
Aims/hypothesis The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2
PR Patel, SK Ramakrishnan, MK Kaw, CK Raphael… - Diabetologia, 2012 - Springer
Aims/hypothesis The carcino-embryonic antigen-related cell adhesion molecule (CEACAM)
2 is produced in many feeding control centres in the brain, but not in peripheral insulin …
2 is produced in many feeding control centres in the brain, but not in peripheral insulin …
Increased glucose-induced secretion of glucagon-like peptide-1 in mice lacking the carcinoembryonic antigen-related cell adhesion molecule 2 (CEACAM2)
SS Ghanem, G Heinrich, SG Lester, V Pfeiffer… - Journal of Biological …, 2016 - ASBMB
Carcinoembryonic antigen-related cell adhesion molecule 2 (CEACAM2) regulates food
intake as demonstrated by hyperphagia in mice with the Ceacam2 null mutation (Cc2−/−) …
intake as demonstrated by hyperphagia in mice with the Ceacam2 null mutation (Cc2−/−) …
Leptin resistance contributes to obesity in mice with null mutation of carcinoembryonic antigen-related cell adhesion molecule 1
G Heinrich, L Russo, TR Castaneda, V Pfeiffer… - Journal of Biological …, 2016 - ASBMB
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic
insulin clearance. Consistently, mice with null mutation of Ceacam1 (Cc1−/−) exhibit …
insulin clearance. Consistently, mice with null mutation of Ceacam1 (Cc1−/−) exhibit …
Loss of hepatic CEACAM1: a unifying mechanism linking insulin resistance to obesity and non-alcoholic fatty liver disease
G Heinrich, HE Ghadieh, SS Ghanem… - Frontiers in …, 2017 - frontiersin.org
The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …
Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis [S]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …