Allele Percentage of the BRAF V600E Mutation in Papillary Thyroid Carcinomas and Corresponding Lymph Node Metastases: No Evidence for a Role in Tumor …
G Gandolfi, V Sancisi, F Torricelli… - The Journal of …, 2013 - academic.oup.com
Context: The relevance of the BRAF V600E mutation in papillary thyroid carcinoma (PTC) as
a negative prognostic factor is a subject of intense debate. This mutation has been …
a negative prognostic factor is a subject of intense debate. This mutation has been …
Co-existence of BRAFV600E and TERT promoter mutations in papillary thyroid carcinoma is associated with tumor aggressiveness, but not with lymph node …
H Ren, Y Shen, D Hu, W He, J Zhou, Y Cao… - Cancer management …, 2018 - Taylor & Francis
Background Mutations of BRAF V600E and TERT promoters are associated with thyroid
cancer development. This study further investigated association of these mutations with …
cancer development. This study further investigated association of these mutations with …
Alterations of the BRAF gene in thyroid tumors
R Ciampi, YE Nikiforov - Endocrine pathology, 2005 - Springer
BRAF belongs to the RAF family of protein kinases that are important components of the
MAPK signaling pathway mediating cell growth, differentiation and survival. Activating point …
MAPK signaling pathway mediating cell growth, differentiation and survival. Activating point …
Mutant BRAFT1799A Can Be Detected in the Blood of Papillary Thyroid Carcinoma Patients and Correlates with Disease Status
KW Cradic, D Milosevic, AM Rosenberg… - The Journal of …, 2009 - academic.oup.com
Context: The BRAF T1799A transversion is the most frequent morphotype-specific somatic
mutation in papillary thyroid carcinoma (PTC). The ability to detect this mutation in the …
mutation in papillary thyroid carcinoma (PTC). The ability to detect this mutation in the …
High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas Correlation with more aggressive phenotype and …
G Oler, JM Cerutti - … Journal of the American Cancer Society, 2009 - Wiley Online Library
BACKGROUND: Although several studies undoubtedly demonstrated that BRAF mutation is
an important genetic event in the pathogenesis of papillary thyroid carcinoma (PTC), its …
an important genetic event in the pathogenesis of papillary thyroid carcinoma (PTC), its …
Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation
L Yip, MN Nikiforova, SE Carty, JH Yim, MT Stang… - Surgery, 2009 - Elsevier
BACKGROUND: To date, a mutation of the BRAF oncogene is the most common genetic
alteration found in papillary thyroid carcinoma (PTC) and is associated with extrathyroidal …
alteration found in papillary thyroid carcinoma (PTC) and is associated with extrathyroidal …
Clinical Significance of BRAF Mutation in Thyroid Papillary Cancer
IJ Fernandez, O Piccin, S Sciascia… - … –Head and Neck …, 2013 - journals.sagepub.com
Objective To correlate the presence of BRAF V600E mutation with clinicopathological
parameters. Study Design Case-control study. Setting BRAF mutation represents the most …
parameters. Study Design Case-control study. Setting BRAF mutation represents the most …
BRAF mutation detection in indeterminate thyroid cytology specimens Underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma
NP Ohori, R Singhal, MN Nikiforova, L Yip… - Cancer …, 2013 - Wiley Online Library
BACKGROUND: BRAF mutations are highly specific for papillary thyroid carcinoma (PTC)
and many cytology specimens with BRAF mutations are expected to demonstrate cytologic …
and many cytology specimens with BRAF mutations are expected to demonstrate cytologic …
The utility of BRAF testing in the management of papillary thyroid cancer
AL Melck, L Yip, SE Carty - The oncologist, 2010 - academic.oup.com
Over the last decade, investigators have developed a clearer understanding of the genetic
alterations underlying thyroid carcinogenesis. A number of biomarkers involved in the …
alterations underlying thyroid carcinogenesis. A number of biomarkers involved in the …
Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAFK601E Mutation
M Afkhami, A Karunamurthy, S Chiosea, MN Nikiforova… - Thyroid, 2016 - liebertpub.com
Background: While the association of the BRAFV600E mutation with aggressive
histopathological tumor features and clinical behavior has been extensively studied in …
histopathological tumor features and clinical behavior has been extensively studied in …