Numerous investigations have indicated that in both health and diseas~ the shortlived
radical nitric oxide (NO) is a key effector in the vascular system (Fig. 1). NO is generated by a …

The formation of nitric oxide (NO) from the amino acid L-arginine is now recognized as a
ubiquitous pathway involved in a number of physiological functions. The generation of NO …

The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric
oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which …

Sustained production of large amounts of nitric oxide (NO) is induced in blood vesselsby
inflammatory stimuli as a result of the expression of the inducible fonn of NO-syntbase (NOS …

In the five years since the discovery that nitric oxide is produced as a signal in blood vessels,
a great deal has been discovered about the processes involved. This article reviews current …

The vascular endothelium is a monolayer of cells between the vessel lumen and the
vascular smooth muscle cells. Nitric oxide (NO) is a soluble gas continuously synthesized …

The free radical nitric oxide has emerged as an important signal and effector molecule that
controls critical functions in the mammalian cardiovascular, immune and nervous systems …

Nitric oxide (NO) decreases cellular oxygen (O2) consumption by competitively inhibiting
cytochrome c oxidase. Here, we show that endogenously released endothelial NO, either …

Since its discovery, endothelium-derived nitric oxide (NO) has become one of the most
intensely investigated molecules in the field of cardiovascular physiology. Although initial …

The vascular endothelium mediates the ability of blood vessels to alter their architecture in
response to hemodynamic changes; however, the specific endothelial-derived factors that …