Change in plasma glutamate concentration during cardiac surgery is a poor predictor of cognitive outcome

JD Reynolds, DW Amory, HP Grocott, WD White… - Journal of cardiothoracic …, 2002 - Elsevier
Objective: To develop a simple and reliable method for quantitating plasma glutamate
concentration and apply this method to monitor systemic glutamate levels during coronary …

Glutamate/aspartate supplementation during cardiopulmonary bypass: effect on postoperative neurocognitive function

DD Erol, HA Ibis - The Heart Surgery Forum, 2008 - journal.hsforum.com
In this randomized trial, we investigated the effect of glutamate/aspartate-containing
cardioplegia on neurocognitive function in 70 patients undergoing first-time elective …

Determination of factors affecting glutamate concentrations in the whole blood of healthy human volunteers

A Zlotnik, S Ohayon, BF Gruenbaum… - Journal of …, 2011 - journals.lww.com
Background Abnormally high concentrations of glutamate in brain fluids have been shown to
be neurotoxic and correlate with a poor neurological outcome following traumatic brain …

[PDF][PDF] Assessment of myocardial glutamate requirements early after coronary artery bypass surgery

I Vanhanen, R Svedjeholm, E Håkanson… - Scandinavian …, 1998 - Taylor & Francis
Glutamate is an important substrate for the intermediary metabolism of the heart, particularly
in association with ischemia. Early after coronary artery bypass surgery (CABG) myocardial …

[HTML][HTML] Glutamate Infusion Reduces Myocardial Dysfunction after Coronary Artery Bypass Grafting According to NT-proBNP: Summary of 2 Randomized Controlled …

J Holm, F Vanky, R Svedjeholm - The American Journal of Clinical Nutrition, 2023 - Elsevier
Background Glutamate is reported to enhance the recovery of oxidative metabolism and
contractile function of the heart after ischemia. The effect appears to be blunted in diabetic …

[HTML][HTML] GLUTAMICS—a randomized clinical trial on glutamate infusion in 861 patients undergoing surgery for acute coronary syndrome

M Vidlund, E Håkanson, Ö Friberg… - The Journal of thoracic …, 2012 - Elsevier
OBJECTIVE: Glutamate has been claimed to protect the heart from ischemia and to facilitate
metabolic and hemodynamic recovery after ischemia. The GLUTAmate for Metabolic …

The S-100B substudy of the GLUTAMICS trial: Glutamate infusion not associated with sustained elevation of plasma S-100B after coronary surgery

M Vidlund, J Holm, E Håkanson, Ö Friberg… - Clinical Nutrition, 2010 - Elsevier
BACKGROUND & AIMS: Concerns have been raised about potential neurological injury
related to exogenous glutamate. In cardiac surgery glutamate has been administered as a …

[HTML][HTML] The impact of glutamate infusion on postoperative NT-proBNP in patients undergoing coronary artery bypass surgery: a randomized study

H Jiang, J Holm, M Vidlund, F Vanky, Ö Friberg… - Journal of Translational …, 2020 - Springer
Background Glutamate, a key intermediate in myocardial metabolism, may enhance
myocardial recovery after ischemia and possibly reduce the incidence and severity of …

Does glutamate influence myocardial and peripheral tissue metabolism after aortic valve replacement for aortic stenosis?

FB Vánky, E Håkanson, L Jorfeldt, R Svedjeholm - Clinical Nutrition, 2006 - Elsevier
BACKGROUND & AIMS: Glutamate plays an important role for myocardial metabolism in
association with ischaemia. Patients with coronary artery disease characteristically …

An increase in extracellular glutamate is a sensitive method of detecting ischaemic neuronal damage during cranial base and cerebrovascular surgery. An in vivo …

A Mendelowitsch, LN Sekhar, DC Wright, A Nadel… - Acta …, 1998 - Springer
All patients undergoing neurological surgery are at risk for serious complications. Ischaemic
damage presenting with hemiparesis or speech difficulties occurs in up to 6% of patients …