Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer
Small cell lung cancer (SCLC) tumors comprise heterogeneous mixtures of cell states,
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
Multivalent state transitions shape the intratumoral composition of small cell lung carcinoma
Studies to date have not resolved how diverse transcriptional programs contribute to the
intratumoral heterogeneity of small cell lung carcinoma (SCLC), an aggressive tumor …
intratumoral heterogeneity of small cell lung carcinoma (SCLC), an aggressive tumor …
Novel hybrid phenotype revealed in small cell lung cancer by a transcription factor network model that can explain tumor heterogeneity
Small cell lung cancer (SCLC) is a devastating disease due to its propensity for early
invasion and refractory relapse after initial treatment response. Although these aggressive …
invasion and refractory relapse after initial treatment response. Although these aggressive …
[HTML][HTML] MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers
Adopting a systems approach, we devise a general workflow to define actionable subtypes
in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four …
in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four …
Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models
D Lissa, N Takahashi, P Desai, I Manukyan… - Nature …, 2022 - nature.com
Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key
transcription regulators have recently been proposed in cell lines and limited number of …
transcription regulators have recently been proposed in cell lines and limited number of …
[HTML][HTML] Tumor heterogeneity in small cell lung cancer defined and investigated in pre-clinical mouse models
Small cell lung carcinoma (SCLC) is a fast-growing, highly metastatic form of lung cancer. A
major difference between SCLC and other forms of lung cancer is that SCLC tumors often …
major difference between SCLC and other forms of lung cancer is that SCLC tumors often …
Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer
Phenotypic (non-genetic) heterogeneity has significant implications for the development and
evolution of organs, organisms, and populations. Recent observations in multiple cancers …
evolution of organs, organisms, and populations. Recent observations in multiple cancers …
[HTML][HTML] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histologic transformation
Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …