The reversible period of hypoxia and ischemia is a consequence of the function of numerous
regulatory mechanisms which convert cells to a quiescent state. Thus, early changes in …

Calcium and hypoxic injury in the renal medulla of the perfused rat kidney. To study the
interaction between calcium and the medullary hypoxic lesions found in isolated perfused …

Retrograde persufflation of ischemic kidneys of dogs via the renal vein with gaseous O 2
was evaluated as a method of kidney preservation (retrograde aerobic ischemia) and …

To study renal cortical and medullary oxygen tensions, we used sensitive Clark-type O2
microelectrodes, inserted by micromanipulators into the cortex and medulla of kidneys of …

Rabbit proximal tubules were incubated aerobically or subjected to anoxia for 30 min
followed by 60 min of reoxygenation. The medium contained (in mM) 5 glucose, 10 butyrate …

Renal medullary blood flow was well maintained for several hours after blood loss which
produced hypotension. Renal cortical blood flow was altered by trauma and mild …

The goal of this study was to determine whether anoxic membrane disruption is initiated by
loss of cytoskeletal support in rabbit renal proximal tubules (PT). We specifically tested 1) …

METHODS Dogs ranging in weight from 15.5 to 2 I kg. were used. All except one were
males. They were anesthetized with 30 “g/kg. of pentobarbital sodium, given iv, with small …

The effects of cold ischemia on the proximal tubule of the rat kidney were studied by light
and electron microscopy in vitro and also in vivo after transplantation. The duration of cold …

The failure of blood flow to return to the kidney following a transient period of ischemia has
long been recognized. The cause of this “no-reflow” has been investigated in the rat after a …