Non-steroidal antiinflammatory drugs (NSAIDs) are known to induce analgesia mainly via
inhibition of cyclooxygenase (COX). Although the inhibition of COX in the periphery is …

Our objective is to analyze and observe the different administration routes of parecoxib
sodium pretreatment on the behavioral improvement of rats with neuropathic pain to provide …

The use of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammatory
pain is limited by gastrointestinal complications. The rapid action of NSAIDs is associated …

Pain is the most common complaint in the medical field and the identification of novel
compounds that can effectively treat painful states without causing side effects remains a …

The analysis of drug's influence on peripheral and central sensitisation can give useful
information about its mode of action and can lead to more efficacy in the treatment of pain …

Duloxetine, a serotonin and noradrenaline reuptake inhibitor, and celecoxib, a non-steroidal
anti-inflammatory drug, are commonly used analgesics for persistent pain, however with …

Most animal models of pain cannot separate the sensory and affective components of pain.
One model that has been used to assess affective pain is the place escape avoidance …

Background The aim of this study was to evaluate the effect of vitamin E co-administration
with celecoxib in thermal and inflammatory pain in two model of pain assessment including …

AIMS: The endogenous opioids mediate the analgesic effects of celecoxib in a model of
mechanical hyperalgesia in rats. As responses to thermal stimuli may differ from those to …

Objective and design: The purpose of the present study was to determine whether the
antinociceptive activity of rofecoxib is mediated, at least in part, through changes in the brain …