Background External medication that is absorbed percutaneously may be used to reduce
inflammation and relieve pain from acute injuries such as ankle sprains and bruises. The …

There are several lines of evidence to suggest that cyclooxygenase-2 (COX-2) plays an
important role in the generation and maintenance of neuropathic pain states following …

The effects of selective cyclooxygenase-2 (COX-2) inhibitors in biological functions are
frequently investigated in animal models. However, there is little data on their analgesic …

Non-steroidal anti-inflammatory drugs (NSAIDs) are thought to exert their pharmacological
actions by a common mechanism: inhibition of cyclooxygenase (COX)-mediated prostanoid …

Background and Purpose Celecoxib (CXB) is a widely prescribed COX-2 inhibitor used
clinically to treat pain and inflammation. Recently, COX-2 independent mechanisms have …

Chronic pain resulting from metastatic bone cancer remains poorly understood and resistant
to treatment. Here we have examined the effect of the novel COX-2 enzyme inhibitor …

OBJECTIVES: There is good evidence that opioids can potentiate analgesic activity of some
older non-opioid analgesics (such as paracetamol or ibuprofen) but it is not known whether …

Purpose Cyclooxygenase-2 inhibitor celecoxib is also used in the dental field for analgesia.
However, there are few reports on the time to onset and duration of analgesia. We …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the best therapeutic options to
treat pain. Their use in combination with other drugs may broaden their applicability in …

The possible anti-inflammatory and antinociceptive effects of nitrendipine, nicardipine,
diltiazem and verapamil were examined with formalin test in the rat paw. Pretreatment with …