The reports of analgesic effects of benzodiazepines are inconsistent. There is evidence of a
hyperalgesic effect induced by activation of supraspinal GABAA receptors and an …

Crotoxin (CTX), a neurotoxin isolated from the venom of the South American rattlesnake
Crotalus durissus terrificus, induces analgesia. In this study, we evaluated the …

Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used as analgesics. Although
the results of clinical studies indicate considerable disparity in the analgesic efficacy of …

Pain represents one of the leading causes of suffering and disability worldwide. Currently
available drugs cannot treat all types of pain and may have adverse effects. Hence, the use …

The anti-inflammatory activity of fluoxetine, a selective serotonin reuptake inhibitor (SSRI),
was studied on the carrageenan-induced paw inflammation in the rat. Fluoxetine (10 …

Pain is such an experience that every human being is faced in his/her lifetime. On one hand,
it is a warning for awareness from tissue damage and on the other hand it is a bad …

Recent evidence suggests that P2X3 receptors express abundantly in nociceptive sensory
neurons and play an important role in neuropathic pain. Upregulation of prostaglandin E2 …

Due to their reduced frequency of dosing and ease of availability, NSAIDs are generally
preferred over opioids for rodent analgesia. We evaluated the efficacy of the highly COX2 …

BACKGROUND: Neuroinflammation triggered by macrophage infiltration into sites of
peripheral nerve injury may result in neuropathic pain. Peroxisome proliferator-activated …

Mechanical hyperalgesia induced in rat paws by carrageenan (250μg) was modified by pre-
treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib …