Acetylcholine turnover rates in rat brain regions during cocaine self‐administration

JE Smith, TC Vaughn, C Co - Journal of neurochemistry, 2004 - Wiley Online Library
The involvement of cholinergic neurons in the brain processes underlying reinforcement has
been recently demonstrated. This experiment assessed the potential role of cholinergic …

Involvement of cholinergic neuronal systems in intravenous cocaine self-administration

JE Smith, C Co, X Yin, GM Sizemore, A Liguori… - Neuroscience & …, 2004 - Elsevier
Recent studies suggest the participation of cholinergic neurons in the brain processes
underlying reinforcement. The involvement of cholinergic neurons in cocaine self …

Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration

JE Smith, TR Koves, C Co - Neuroscience, 2003 - Elsevier
The turnover rates of dopamine, norepinephrine, serotonin, aspartate, glutamate and GABA
were measured in 27 brain regions of rats self-administering cocaine and in yoked cocaine …

Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine

JM Wilson, ME Carroll, ST Lac, LM DiStefano… - Neuroscience letters, 1994 - Elsevier
Choline acetyltransferase (ChAT) activity was measured in discrete areas of rat brain after
chronic, unlimited access to self-administration of cocaine. Mean activity of ChAT was …

Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats

GP Mark, A Hajnal, AE Kinney, AS Keys - Psychopharmacology, 1999 - Springer
Rationale: The neurochemical effects of psychostimulant exposure may depend on how
these drugs are encountered. A useful method for examining this issue is to compare …

Cholinergic interneurons of the nucleus accumbens and dorsal striatum are activated by the self-administration of cocaine

ML Berlanga, CM Olsen, V Chen, A Ikegami… - Neuroscience, 2003 - Elsevier
The nucleus accumbens, a major component of the ventral striatum, and the dorsal striatum
are primary targets of the mesolimbic dopamine pathway, which is a pathway that plays a …

Limbic acetylcholine turnover rates correlated with rat morphine-seeking behaviors

JE Smith, C Co, JD Lane - Pharmacology Biochemistry and Behavior, 1984 - Elsevier
Acetylcholine (ACh) turnover rates were measured in fourteen brain regions of rats
intravenously self-administering morphine and in yoked-morphine and yoked-vehicle …

Rat brain neurotransmitter turnover rates altered during withdrawal from chronic cocaine administration

SI Dworkin, C Co, JE Smith - Brain research, 1995 - Elsevier
This experiment utilized neurotransmitter turnover rates to assess the effects of withdrawal
from cocaine on the brain. A triad-littermate design was used to evaluate the importance of …

Cocaine disposition in discrete regions of rat brain

JI Javaid, JM Davis - Biopharmaceutics & drug disposition, 1993 - Wiley Online Library
It has been proposed that various effects of psychoactive drugs on the central nervous
system may be related to the capacity of the drug to selectively concentrate in specific …

Altered neural cholinergic receptor systems in cocaine-addicted subjects

B Adinoff, MD Devous, MJ Williams, SE Best… - …, 2010 - nature.com
Abstract Changes in the brain's cholinergic receptor systems underlie several
neuropsychiatric disorders, including Alzheimer's disease, schizophrenia, and depression …